Morey-Holton E R, Schnoes H K, DeLuca H F, Phelps M E, Klein R F, Nissenson R H, Arnaud C D
Space Biology Branch, NASA-Ames Research Center, Moffett Field, CA 94035.
Aviat Space Environ Med. 1988 Nov;59(11 Pt 1):1038-41.
The purpose of this study was to determine whether plasma levels of the vitamin D hormone and parathyroid hormone (PTH), two potent activators of bone remodeling sites, were altered in four astronauts during the 8-day (d) Spacelab 2 mission (SL2). Increased circulating levels of either hormone could change calcium homeostasis and bone cell activity and, thus, contribute to bone loss in crewmembers in space. The vitamin D hormone was elevated in all astronauts at the end of the first inflight day but returned to normal by the seventh day. Biologically active PTH tended to be normal throughout the mission. Both hormones were within the normal range by the end of the 8-d flight of this SL2 crew. Plasma levels of 25OHD, 24,25(OH)2D, calcium, phosphorus, and albumin were essentially normal during the mission.
本研究的目的是确定在为期8天的太空实验室2号任务（SL2）期间，四名宇航员体内两种强效骨重塑位点激活剂——维生素D激素和甲状旁腺激素（PTH）的血浆水平是否发生了变化。这两种激素中任何一种循环水平的升高都可能改变钙稳态和骨细胞活性，从而导致太空船员骨质流失。在飞行首日结束时，所有宇航员的维生素D激素水平均升高，但到第七天时恢复正常。在整个任务期间，具有生物活性的PTH往往处于正常水平。在该SL2机组人员8天飞行结束时，两种激素均在正常范围内。在任务期间，25OHD、24,25(OH)2D、钙、磷和白蛋白的血浆水平基本正常。
