倾听：浆细胞样树突状细胞、单核细胞衍生的树突状细胞和中性粒细胞在抗真菌防御中的相互作用。
Listening In: Plasmacytoid DC, Monocyte-Derived DC, and Neutrophil Crosstalk in Antifungal Defense.
机构信息
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cell Host Microbe. 2020 Jul 8;28(1):9-11. doi: 10.1016/j.chom.2020.06.015.
Abstract
Plasmacytoid DCs (pDCs) are typically thought to be key in antiviral defense. In this issue of Cell Host & Microbe, Guo, Kasahara et al. (2020) reveal a critical role for pDCs in antifungal immunity. Aspergillus-infected monocyte-derived DCs and neutrophils recruit pDCs, which promote neutrophil fungicidal activity.
摘要
浆细胞样树突状细胞 (pDCs) 通常被认为是抗病毒防御的关键。在本期《Cell Host & Microbe》中，Guo、Kasahara 等人（2020 年）揭示了 pDCs 在抗真菌免疫中的关键作用。烟曲霉感染的单核细胞衍生的 DC 和中性粒细胞招募 pDCs，pDCs 促进中性粒细胞的杀菌活性。
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