关于 NDH-1 的结构和功能的最新进展：需氧光合作用的复合物 I。
Recent advances on the structure and function of NDH-1: The complex I of oxygenic photosynthesis.
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
出版信息
Biochim Biophys Acta Bioenerg. 2020 Nov 1;1861(11):148254. doi: 10.1016/j.bbabio.2020.148254. Epub 2020 Jul 6.
Photosynthetic NADH dehydrogenase-like complex type-1 (a.k.a, NDH, NDH-1, or NDH-1L) is a multi-subunit, membrane-bound oxidoreductase related to the respiratory complex I. Although originally discovered 30 years ago, a number of recent advances have revealed significant insight into the structure, function, and physiology of NDH-1. Here, we highlight progress in understanding the function of NDH-1 in the photosynthetic light reactions of both cyanobacteria and chloroplasts from biochemical and structural perspectives. We further examine the cyanobacterial-specific forms of NDH-1 that possess vectorial carbonic anhydrase (vCA) activity and function in the CO-concentrating mechanism (CCM). We compare the proposed mechanism for the cyanobacterial NDH-1 vCA-activity to that of the DAB (DABs accumulates bicarbonate) complex, another putative vCA. Finally, we discuss both new and remaining questions pertaining to the mechanisms of NDH-1 complexes in light of these recent advances.
光合 NADH 脱氢酶样复合体 1 型（又称 NDH、NDH-1 或 NDH-1L）是一种多亚基、膜结合的氧化还原酶，与呼吸复合物 I 有关。尽管它最初是在 30 年前发现的，但最近的一些进展揭示了对 NDH-1 的结构、功能和生理学的重要见解。在这里，我们从生物化学和结构的角度强调了对 NDH-1 在蓝细菌和叶绿体光合作用光反应中的功能的理解进展。我们进一步研究了具有载体碳酸酐酶（vCA）活性并在 CO2 浓缩机制（CCM）中发挥作用的蓝细菌特异性 NDH-1 形式。我们比较了蓝细菌 NDH-1 vCA-活性的拟议机制与另一种假定的 vCA——DAB（DABs 积累重碳酸盐）复合物的机制。最后，我们根据这些最新进展讨论了与 NDH-1 复合物的机制有关的新问题和遗留问题。
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