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Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.达雷妥尤单抗、来那度胺、硼替佐米和地塞米松用于适合移植的新诊断多发性骨髓瘤：GRIFFIN 试验。
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Overall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomised, open-label, phase 3 trial.达雷妥尤单抗联合硼替佐米、美法仑和泼尼松治疗新诊断多发性骨髓瘤（ALCYONE）的总生存：一项随机、开放标签、3 期临床试验。
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多发性骨髓瘤中的微小残留病：现状与未来展望。

Minimal Residual Disease in Multiple Myeloma: State of the Art and Future Perspectives.

作者信息

Mina Roberto, Oliva Stefania, Boccadoro Mario

机构信息

Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città dellaSalute e della Scienza di Torino, via Genova 3, 10126 Torino, Italy.

出版信息

J Clin Med. 2020 Jul 7;9(7):2142. doi: 10.3390/jcm9072142.

DOI:10.3390/jcm9072142
PMID:32645952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7408660/
Abstract

Minimal residual disease (MRD) detection represents a sensitive tool to appropriately measure the response obtained with therapies for multiple myeloma (MM). The achievement of MRD negativity has superseded the conventional complete response (CR) and has been proposed as a surrogate endpoint for progression-free survival and overall survival. Several techniques are available for the detection of MRD inside (next-generation sequencing, flow cytometry) and outside (PET/CT, magnetic resonance) the bone marrow, and their complementary use allows a precise definition of the efficacy of anti-myeloma treatments. This review summarizes MRD data and results from previous clinical trials, highlights open issues related to the role of MRD in MM and discusses how MRD could be implemented in clinical practice to inform on patient prognosis and drive therapeutic decisions.

摘要

微小残留病（MRD）检测是一种灵敏的工具，可用于恰当衡量多发性骨髓瘤（MM）治疗所取得的疗效。实现MRD阴性已取代了传统的完全缓解（CR），并被提议作为无进展生存期和总生存期的替代终点。有多种技术可用于检测骨髓内（下一代测序、流式细胞术）和骨髓外（PET/CT、磁共振）的MRD，它们的互补使用能够精确界定抗骨髓瘤治疗的疗效。本综述总结了MRD数据及既往临床试验结果，突出了与MRD在MM中的作用相关的未决问题，并讨论了如何在临床实践中应用MRD来了解患者预后并指导治疗决策。