Molander Peter, Novo Mehmed, Hållstam Andrea, Löfgren Monika, Stålnacke Britt-Marie, Gerdle Björn
Pain and Rehabilitation Centre and Department of Health, Medicine and Caring Sciences, Linköping University, 581 83 Linköping, Sweden.
Department of Behavioural Sciences and Learning, Linköping University, 581 83 Linköping, Sweden.
J Clin Med. 2020 Jul 7;9(7):2143. doi: 10.3390/jcm9072143.
Although chronic pain is common in patients with Ehlers-Danlos syndrome (EDS) and hypermobility syndromes (HMS), little is known about the clinical characteristics of these groups. The main aim was to compare EDS/HMS with common local and generalized pain conditions with respect to Patient Reported Outcome Measures (PROMs). Data from the Swedish Quality Register for Chronic Pain (SQRP) from 2007 to 2016 ( = 40,518) were used, including patients with EDS/HMS ( = 795), fibromyalgia ( = 5791), spinal pain ( = 6693), and whiplash associated disorders (WAD) ( = 1229). No important differences in the PROMs were found between EDS and HMS. Women were represented in > 90% of EDS/HMS cases and fibromyalgia cases, and in about 64% of the other groups. The EDS/HMS group was significantly younger than the others but had a longer pain duration. The pain intensity in EDS/HMS was like those found in spinal pain and WAD; fibromyalgia had the highest pain intensity. Depressive and anxiety symptoms were very similar in the four groups. Vitality-a proxy for fatigue-was low both in EDS/HMS and fibromyalgia. The physical health was lower in EDS/HMS and fibromyalgia than in the two other groups. Patients with EDS/HMS were younger, more often female, and suffered from pain for the longest time compared with patients who had localized/regional pain conditions. Health-care clinicians must be aware of these issues related to EDS/HMS both when assessing the clinical presentations and planning treatment and rehabilitation interventions.
尽管慢性疼痛在埃勒斯-当洛综合征（EDS）和关节过度活动综合征（HMS）患者中很常见，但对于这些群体的临床特征却知之甚少。主要目的是就患者报告结局量表（PROMs）将EDS/HMS与常见的局部和全身性疼痛病症进行比较。使用了瑞典慢性疼痛质量登记处（SQRP）2007年至2016年的数据（n = 40,518），包括EDS/HMS患者（n = 795）、纤维肌痛患者（n = 5791）、脊柱疼痛患者（n = 6693）和挥鞭样损伤相关疾病（WAD）患者（n = 1229）。在PROMs方面，未发现EDS和HMS之间有重要差异。在EDS/HMS病例和纤维肌痛病例中，女性占比超过90%，在其他组中约占64%。EDS/HMS组明显比其他组年轻，但疼痛持续时间更长。EDS/HMS的疼痛强度与脊柱疼痛和WAD中的疼痛强度相似；纤维肌痛的疼痛强度最高。四组中的抑郁和焦虑症状非常相似。活力（一种疲劳指标）在EDS/HMS和纤维肌痛中都很低。EDS/HMS和纤维肌痛患者的身体健康状况低于其他两组。与患有局部/区域性疼痛病症的患者相比，EDS/HMS患者更年轻，女性更多，且疼痛时间最长。医疗保健临床医生在评估临床表现以及规划治疗和康复干预措施时，必须了解与EDS/HMS相关的这些问题。
