Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Crit Rev Biochem Mol Biol. 2020 Aug;55(4):354-371. doi: 10.1080/10409238.2020.1787325. Epub 2020 Jul 9.
Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) exhibits multiple functions separate and distinct from its historic role in energy production. Further, it exhibits dynamic changes in its subcellular localization which is an a priori requirement for its multiple activities. Separately, moonlighting GAPDH may function in the pathology of human disease, involved in tumorigenesis, diabetes, and age-related neurodegenerative disorders. It is suggested that moonlighting GAPDH function may be related to specific modifications of its protein structure as well as the formation of GAPDH protein: protein or GAPDH protein: nucleic acid complexes.
兼职甘油醛-3-磷酸脱氢酶 (GAPDH) 表现出多种与其在能量产生中的历史作用分离且不同的功能。此外，它还表现出亚细胞定位的动态变化，这是其多种活性的先决条件。此外，兼职 GAPDH 可能在人类疾病的病理学中发挥作用，涉及肿瘤发生、糖尿病和与年龄相关的神经退行性疾病。有人认为，兼职 GAPDH 功能可能与其蛋白质结构的特定修饰以及 GAPDH 蛋白：蛋白质或 GAPDH 蛋白：核酸复合物的形成有关。
