Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Department of Obstetrics and Gynecology, University of Mississippi Medical Center , Jackson, MS, USA.
Hypertens Pregnancy. 2020 Nov;39(4):399-404. doi: 10.1080/10641955.2020.1793999. Epub 2020 Jul 10.
The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS). Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats.
On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19.
MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN.
TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.
先兆子痫的 RUPP 大鼠模型表现出高血压（MAP）、细胞溶解自然杀伤（cNK）细胞、肿瘤坏死因子-α（TNF-α）和线粒体活性氧（mtROS）。目的：用 ETAN（依那西普）阻断 TNF-α 是否会减少 RUPP 大鼠中的 cNK 细胞和 mtROS。
在妊娠第 14 天进行 RUPP 手术，在第 18 天给予 ETAN（0.4mg/kg），在第 19 天收集 MAP、血液和组织。
与 NP 相比，RUPP 大鼠的 MAP、细胞溶解 NK 细胞和 mtROS 升高，用 ETAN 可使其正常化。
TNF-α 阻断可降低血压，并改善胎盘缺血引起的炎症和器官功能。
