Department of Anatomical Pathology, LabPlus, Auckland City Hospital, 2 Park Road, Grafton, Auckland, New Zealand; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand.
Department of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, 22-30 Park Road, Grafton, Auckland, New Zealand.
J Clin Neurosci. 2020 Oct;80:324-330. doi: 10.1016/j.jocn.2020.06.011. Epub 2020 Jul 6.
The incidence of meningioma is known to vary by gender and ethnicity. This study aimed to describe the epidemiological characteristics of a 10-year cohort of patients undergoing meningioma resection at Auckland City Hospital, Auckland, New Zealand. Of particular interest was whether there was any difference in meningioma incidence and recurrence rates between New Zealand Maori and Pacific Island patients compared with other ethnic groups. The study was a retrospective analysis of 493 patients with pathologically confirmed meningioma over the period 1 January 2002 to 31 December 2011. Based on this neurosurgical cohort, the minimum incidence of meningioma in the Auckland region was 3.39 per 100,000 population per year (95% C.I. 3.02-3.80) for the study period. Meningioma was significantly more common in women than men by a ratio of 4.2:1. New Zealand Maori and Pacific Island patients had a significantly higher incidence of meningioma than other ethnic groups. New Zealand Maori had a meningioma incidence 2.74 times that of Europeans (95% C.I. 2.01-3.73, p < 0.001). Pacific Island patients had 2.03 times higher incidence of meningioma than Europeans (95% C.I. 1.42 - 2.89, p < 0.001). The overall meningioma recurrence rate was 21.6% with a mean follow-up of 77 months. Recurrence rates for meningioma among Pacific Island patients were significantly higher than for other ethnic groups (hazard ratio 1.73, p = 0.008). Multivariate analysis of clinical variables confirmed the significance of traditional prognostic factors such as WHO tumour grade and Simpson grade of surgical excision in predicting meningioma recurrence.
脑膜瘤的发病率已知因性别和种族而异。本研究旨在描述新西兰奥克兰市奥克兰市医院接受脑膜瘤切除术的 10 年队列患者的流行病学特征。特别感兴趣的是，与其他种族群体相比，新西兰毛利人和太平洋岛民患者的脑膜瘤发病率和复发率是否存在差异。该研究是对 2002 年 1 月 1 日至 2011 年 12 月 31 日期间经病理证实的 493 例脑膜瘤患者的回顾性分析。基于这个神经外科队列，奥克兰地区脑膜瘤的最低发病率为每年每 10 万人 3.39 例（95%置信区间为 3.02-3.80）。脑膜瘤在女性中的发病率明显高于男性，比例为 4.2:1。新西兰毛利人和太平洋岛民患者的脑膜瘤发病率明显高于其他种族群体。新西兰毛利人的脑膜瘤发病率是欧洲人的 2.74 倍（95%置信区间为 2.01-3.73，p<0.001）。太平洋岛民患者的脑膜瘤发病率比欧洲人高 2.03 倍（95%置信区间为 1.42-2.89，p<0.001）。总体脑膜瘤复发率为 21.6%，平均随访时间为 77 个月。太平洋岛民患者的脑膜瘤复发率明显高于其他种族群体（危险比 1.73，p=0.008）。对临床变量的多变量分析证实了传统预后因素如世界卫生组织肿瘤分级和手术切除 Simpson 分级在预测脑膜瘤复发中的重要性。
