Davudov M M, Harirchi I, Arabkheradmand A, Garajei A, Mirzajani Z, Amiraliyev K, Rustamli N, Zebardast J, Montazeri A
Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Oral and Maxillofacial Surgery, Azerbaijan Medical University, Baku, Azerbaijan.
Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Br J Oral Maxillofac Surg. 2020 Nov;58(9):e67-e74. doi: 10.1016/j.bjoms.2020.06.027. Epub 2020 Jul 6.
This was a prospective clinical study and the purpose was to assess the quality of life (QoL) as the primary endpoint for patients given prospective treatment for cancer of the oral cavity that required reconstruction using various reconstruction methods in Azerbaijan. All patients who were operated on during the year 2017 to 2018 were entered into the study. Quality of life was assessed six months postoperatively using the European Organization for Research and Cancer Treatment Core Cancer Quality of Life (EORTC QLQ-C30) and the Head and Neck Specific Quality of Life (QLQ-H&NN43) questionnaires. A total of 96 patients completed the questionnaires. There were 36 patients who did not receive a flap, 31 patients received a local flap, and 29 patients had distant-regional flaps. QoL assessed by the EORTC QLQ-C30, and the QLQ-H&N43 was lower in patients who received a local flap. In general, the results showed that the reconstruction with a distant-regional flap compared with no flap and local flap leads to improved quality of life of patients with oral cancer.
这是一项前瞻性临床研究，目的是评估生活质量（QoL），将其作为在阿塞拜疆接受口腔癌前瞻性治疗且需采用多种重建方法进行重建的患者的主要终点。纳入了2017年至2018年期间所有接受手术的患者。术后六个月使用欧洲癌症研究与治疗组织核心癌症生活质量问卷（EORTC QLQ-C30）和头颈部特异性生活质量问卷（QLQ-H&NN43）对生活质量进行评估。共有96名患者完成了问卷。36名患者未接受皮瓣移植，31名患者接受了局部皮瓣移植，29名患者接受了远隔区域皮瓣移植。接受局部皮瓣移植的患者经EORTC QLQ-C30和QLQ-H&N43评估的生活质量较低。总体而言，结果表明，与未接受皮瓣移植和接受局部皮瓣移植相比，采用远隔区域皮瓣移植进行重建可改善口腔癌患者的生活质量。
