Campbell G A, Morgan D J, Kumar K, Crankshaw D P
Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
Br J Clin Pharmacol. 1988 Aug;26(2):187-90. doi: 10.1111/j.1365-2125.1988.tb03386.x.
The pharmacokinetics of propofol were investigated following bolus intravenous administration of 2-3 mg kg-1 of drug to eight surgical patients. Apparent elimination half-life, volume of distribution and systemic blood clearance of propofol correlated strongly with the sampling period, which ranged from 8 to 52 h, depending on the time taken for the propofol concentration to reach the detection limit of the assay. In the three patients in whom the sampling period exceeded 42 h, apparent elimination half-life (55.6 h) and apparent volume of distribution (1370 l) greatly exceeded previously published estimates and systemic blood clearance (1020 ml min-1) was much less than previous estimates. This suggests that previous estimates were biased by the relatively short duration of blood collection in those studies (8 to 12 h).
在对8名外科手术患者静脉推注2 - 3 mg/kg的丙泊酚后，研究了丙泊酚的药代动力学。丙泊酚的表观消除半衰期、分布容积和全身血药清除率与采样期密切相关，采样期为8至52小时，这取决于丙泊酚浓度达到检测限所需的时间。在3名采样期超过42小时的患者中，表观消除半衰期（55.6小时）和表观分布容积（1370升）大大超过先前公布的估计值，全身血药清除率（1020毫升/分钟）远低于先前估计值。这表明先前的估计值受到那些研究中相对较短的采血时间（8至12小时）的影响而存在偏差。
