[丙泊酚作为成人诱导麻醉剂的药代动力学]
[Pharmacokinetics of propofol as an induction agents in adults].
作者信息
Landais A, Cockshott I D, Coppens M C, Cohn N, Richard M D, Saint-Maurice C
机构信息
Département d'Anesthésie-Réanimation, Centre Hospitalier d'Argenteuil, Paris.
出版信息
Cah Anesthesiol. 1987 Oct;35(6):427-8.
PMID:3500758
Abstract
The disposition kinetics of Propofol have been determined in 7 patients (3 men, 4 women) receiving 2.5 mg/kg for induction of anaesthesia. Peripheral venous samples were collected up to 12 hours after injection of the drug. Data analysis indicates a 3 compartment model with a terminal half-life of 480 +/- 141 min, clearance of 0.0352 +/- 0.0014 l/min/kg and volume of distribution of 24.2 +/- 6.2 l/kg.
摘要
已在7例接受2.5mg/kg丙泊酚诱导麻醉的患者（3例男性，4例女性）中测定了丙泊酚的处置动力学。在注射药物后长达12小时采集外周静脉血样。数据分析表明为三室模型，终末半衰期为480±141分钟，清除率为0.0352±0.0014升/分钟/千克，分布容积为24.2±6.2升/千克。
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