Adam H K, Glen J B, Hoyle P A
Br J Anaesth. 1980 Aug;52(8):743-6. doi: 10.1093/bja/52.8.743.
Blood concentrations of ICI 35 868 have been determined in rat, pig, rabbit and cat after single i.v. injections. In all species the initial distribution volume was greater than blood volume and the overall distribution volume was large. Half-lives of the distribution phase were extremely short (1-6 min) and the terminal half-lives were also short (16-55 min). In all species examined a correlation existed between the systemic blood concentration of ICI 35 868 and duration of sleep, with concentrations in the range 1-4 micrograms ml-1 being effective in producing unconsciousness. No changes in pharmacokinetics or in the effective concentration occurred on repeated administration or after infusion.
在大鼠、猪、兔和猫单次静脉注射ICI 35 868后，已测定其血药浓度。在所有物种中，初始分布容积大于血容量，总分布容积也很大。分布相的半衰期极短（1 - 6分钟），终末半衰期也较短（16 - 55分钟）。在所有受试物种中，ICI 35 868的全身血药浓度与睡眠时间之间存在相关性，浓度在1 - 4微克/毫升范围内可有效地产生意识丧失。重复给药或输注后，药代动力学或有效浓度均未发生变化。
