Department of Dentistry and Oral Surgery, Hokkaido Cancer Center, 3-54, Kikusui4-Jyo 2-Tyoume, Shiroishi-Ku, Sapporo, Japan.
Department of Radiology, Hokkaido Cancer Center, 3-54, Kikusui4-Jyo 2-Tyoume, Shiroishi-Ku, Sapporo, Japan.
Sci Rep. 2020 Jul 9;10(1):11385. doi: 10.1038/s41598-020-68428-x.
Development of quantitative analysis software has enabled application of several standardised uptake values (SUV) for bone analysis in single photon emission computed tomography (SPECT). The present retrospective study aimed to develop a reliable method of monitoring bone inflammatory activity in antiresorptive agent-related osteonecrosis of the jaw (ARONJ) using SPECT quantitative analysis software. Fifteen ARONJ patients underwent SPECT before and after anti-inflammatory therapy. We calculated the mean maximum SUV (SUVmax) of the bilateral cranial bones using quantitative analysis software and used this as the control [C]. We attempted to adjust the SUVmax of the lesion [L] as follows: adjusted SUVmax (aSUVmax) = [L] - [C]. The optimum threshold to calculate the metabolic bone volume (MBV) (cm) was [C] + 3. The threshold values obtained for each case were input to calculate MBV at each osteomyelitis site. Retrospectively, we compared aSUVmax and MBV of each patient's ARONJ before and after anti-inflammatory therapy. The patients' high aSUVmax or large MBV of the ARONJ reduced rapidly, reflecting individual clinical findings after treatment. Application of SPECT quantitative analysis software to monitor bone inflammatory activity in ARONJ could improve the prognosis-deciding abilities of clinicians and enable them to treat ARONJ effectively.
定量分析软件的发展使得在单光子发射计算机断层扫描（SPECT）中可以应用几种标准化摄取值（SUV）进行骨分析。本回顾性研究旨在开发一种使用 SPECT 定量分析软件监测抗吸收剂相关性颌骨坏死（ARONJ）中骨炎症活性的可靠方法。15 例 ARONJ 患者在抗炎治疗前后进行了 SPECT 检查。我们使用定量分析软件计算双侧颅骨的平均最大 SUV（SUVmax），并将其作为对照 [C]。我们尝试如下调整病变 [L] 的 SUVmax：调整后的 SUVmax（aSUVmax）=[L]-[C]。计算代谢骨体积（MBV）（cm）的最佳阈值为 [C]+3。将每个病例获得的阈值值输入到每个骨髓炎部位计算 MBV。回顾性地，我们比较了 ARONJ 患者在抗炎治疗前后的 aSUVmax 和 MBV。患者的 ARONJ 高 aSUVmax 或大 MBV 迅速减少，反映了治疗后的个体临床发现。将 SPECT 定量分析软件应用于监测 ARONJ 中的骨炎症活性可以提高临床医生的预后判断能力，并使他们能够有效地治疗 ARONJ。
