Department of Dentistry and Oral-Maxillofacial Surgery, School of Medicine, Fujita Health University, 1-98, Dengakugakubo, Kutsukake, Toyoake, Aichi, 470-1192, Japan.
Faculty of Radiological Technology, School of Health Sciences, Fujita Health University, 1-98, Dengakugakubo, Kutsukake, Toyoake, Aichi, 470-1192, Japan.
Ann Nucl Med. 2021 Jul;35(7):853-860. doi: 10.1007/s12149-021-01624-5. Epub 2021 May 16.
Quantitative analyses of gamma-ray accumulation in single-photon emission computed tomography (SPECT), and the evaluation of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) have been reported recently. However, the relationship between the quantitative parameters calculated from SPECT and the detailed morphological changes observed in computed tomography (CT) remains unclear. This study aimed to investigate patients' characteristics and morphological changes observed on CT, and their effects on the quantitative values in SPECT.
From April 2017 to March 2019, patients diagnosed with ARONJ at our hospital were enrolled. The data obtained before September 2017 were reviewed retrospectively, and other data were collected prospectively. CT scans were evaluated for internal texture, sequestrum formation, periosteal reaction, cortical perforation, bone expansion, and pathological fracture. For quantitative assessment, the ratio of the maximum standardized uptake value (SUV) to the mean SUV in the temporal bone (rSUVmax) was calculated from SPECT images. The factors affecting rSUVmax were investigated by multiple regression analysis. The statistical significance level was set at α = 0.05.
Overall, 55 lesions of 42 patients (median age and interquartile range, 75 [67-80 years], 27 female) were evaluated. Male sex (p = 0.007) and bilateral location (p < 0.0001) were selected as variables in the multivariate analysis. Adjusted coefficient of determination R was 0.59 (p < 0.0001).
Sex and horizontal progression of the disease may affect individually calibrated SUVs in SPECT for patients with ARONJ.
最近有研究报道了单光子发射计算机断层扫描（SPECT）中伽马射线积累的定量分析，以及抗吸收剂相关的颌骨坏死（ARONJ）的评估。然而，SPECT 计算的定量参数与 CT 观察到的详细形态变化之间的关系尚不清楚。本研究旨在探讨患者的特征和 CT 观察到的形态变化及其对 SPECT 中定量值的影响。
2017 年 4 月至 2019 年 3 月，我院收治了 ARONJ 患者。回顾性分析 2017 年 9 月前获得的数据，并前瞻性收集其他数据。对 CT 扫描进行内部纹理、死骨形成、骨膜反应、皮质穿孔、骨扩张和病理性骨折评估。对于定量评估，从 SPECT 图像计算最大标准化摄取值（SUV）与颞骨平均 SUV 的比值（rSUVmax）。通过多元回归分析探讨影响 rSUVmax 的因素。统计显著性水平设为α=0.05。
共有 42 例患者的 55 个病灶（中位数年龄和四分位间距为 75[67-80 岁]，27 名女性）进行了评估。多变量分析中选择了男性性别（p=0.007）和双侧病变位置（p<0.0001）作为变量。调整后的决定系数 R 为 0.59（p<0.0001）。
性别和疾病的横向进展可能会影响 ARONJ 患者 SPECT 中个体校准的 SUV。
