一种用于评估颌骨单光子发射计算机断层扫描（SPECT）靶向药物相关性颌骨坏死的新型体模的研发。
Development of a novel phantom for evaluating jawbone SPECT targeting medication-related osteonecrosis of the jaw.
作者信息
Hayashi Naoya, Matsutomo Norikazu, Tokorodani Ryotaro, Fukami Mitsuha, Nishimori Miki, Iwasa Hitomi, Nakatani Kie, Yamamoto Tetsuya, Yamagami Takuji, Yamamoto Tomoaki
机构信息
Division of Radiology, Department of Medical Technology, Kochi Medical School Hospital, Kohasu, Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University, B-524, 5-4-1 Shimorenjaku, Mitaka, Tokyo, 181-8612, Japan.
出版信息
Oral Radiol. 2025 Feb 27. doi: 10.1007/s11282-025-00809-2.
OBJECTIVE
We developed a new phantom for technical evaluation of jawbone single-photon emission computed tomography (SPECT) examinations for medication-related osteonecrosis of the jaw (MRONJ). In this study, we verified the utility of the phantom by determining optimal image reconstruction parameters.
METHODS
We evaluated the image quality and quantification in jawbone SPECT images obtained by different reconstruction parameters using the phantom. The phantom images were acquired using a SPECT/computed tomography (CT) system and then reconstructed using ordered-subset expectation maximization (OSEM) iterative reconstruction with resolution recovery as well as scatter and attenuation correction with various update numbers and Gaussian filter full width at half maximums (FWHMs). The percent contrast (%contrast) and absolute recovery coefficient were calculated to determine the optimal reconstruction parameters (OSEM). Nineteen patients with a clinical diagnosis of MRONJ who underwent bone SPECT/CT were enrolled for the clinical study. The performance of OSEM was verified by comparison with OSEM determined by a spherical phantom, using the correlation between the mean standardized uptake value (SUV) and clinical staging and visual assessment as endpoints.
RESULTS
In the phantom study, %contrast and absolute recovery coefficient increased with increasing update numbers. As the Gaussian filter FWHM increased, the quantitative accuracy and image sharpness decreased. The parameter determined by the phantom study (OSEM) recommended 120 updates and no filter. In the clinical study, the mean and standard deviation of SUV obtained from OSEM were 8.9 ± 1.4 for stage 1 lesions, 12.9 ± 4.1 for stage 2 lesions, and 13.8 ± 1.4 for stage 3 lesions. For OSEM, they were 5.4 ± 2.3 for stage 1 lesions, 8.3 ± 2.5 for stage 2 lesions, and 8.0 ± 0.9 for stage 3 lesions. The SUV obtained from OSEM had a stronger correlation with clinical stage. Based on visual assessment, the quality of the SPECT images reconstructed by OSEM (3.7 ± 0.9) was superior to that reconstructed by OSEM (2.9 ± 1.1).
CONCLUSIONS
We developed a novel phantom and adapted it for technical evaluation. This study demonstrated the utility of the developed phantom.
目的
我们开发了一种新的体模，用于对颌骨单光子发射计算机断层扫描（SPECT）检查进行技术评估，以诊断与药物相关的颌骨骨坏死（MRONJ）。在本研究中，我们通过确定最佳图像重建参数来验证该体模的实用性。
方法
我们使用该体模评估了不同重建参数下获得的颌骨SPECT图像的图像质量和定量分析。使用SPECT/计算机断层扫描（CT）系统采集体模图像，然后使用有序子集期望最大化（OSEM）迭代重建，并进行分辨率恢复以及采用不同更新次数和高斯滤波器半高宽（FWHM）的散射和衰减校正。计算对比度百分比（%对比度）和绝对恢复系数，以确定最佳重建参数（OSEM）。19例临床诊断为MRONJ且接受了骨SPECT/CT检查的患者被纳入临床研究。以平均标准化摄取值（SUV）与临床分期之间的相关性以及视觉评估为终点，通过与球形体模确定的OSEM进行比较，验证OSEM的性能。
结果
在体模研究中，%对比度和绝对恢复系数随着更新次数的增加而增加。随着高斯滤波器FWHM的增加，定量准确性和图像清晰度降低。体模研究确定的参数（OSEM）推荐120次更新且不使用滤波器。在临床研究中，OSEM获得的SUV的平均值和标准差在1期病变中为8.9±1.4，2期病变中为12.9±4.1，3期病变中为13.8±1.4。对于OSEM，1期病变中为5.4±2.3，2期病变中为8.3±2.5，3期病变中为8.0±0.9。OSEM获得的SUV与临床分期的相关性更强。基于视觉评估，OSEM重建的SPECT图像质量（3.7±0.9）优于OSEM重建的图像质量（2.9±1.1）。
结论
我们开发了一种新型体模并将其应用于技术评估。本研究证明了所开发体模的实用性。
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