a homolog of mice MPV17, enhances osmotic stress tolerance.

Mutation in the human gene or the functional yeast orthologue result in mitochondrial DNA depletion. homologs are also found in plants including , but the function of these genes remain unclear. genome contains 10 homologs. Among these, the AtMPV17 protein was localized in mitochondria as MPV17 and SYM1. The yeast knock out mutant cannot grow on ethanol-containing medium at 37 °C. complements the ethanol growth defection of yeast ortholog cells at 37 °C, suggesting that is a functional ortholog of . knock out mutant, show similar growth and seed development to those of the wild-type plant on normal growth condition. However, mutant is more sensitive to ABA and mannitol during germination and seedling growth than wild type plants. Growth retardation of the knock out mutant on medium containing ABA and mannitol is complemented by overexpression. These results suggest that the contributes to osmotic stress tolerance in plants.