Krinsky-McHale Sharon J, Zigman Warren B, Lee Joseph H, Schupf Nicole, Pang Deborah, Listwan Tracy, Kovacs Cynthia, Silverman Wayne
New York State Institute for Basic Research in Developmental Disabilities Staten Island New York USA.
Department of Neurology College of Physicians and Surgeons Columbia University Sergievsky Center/Taub Institute New York New York USA.
Alzheimers Dement (Amst). 2020 Jul 5;12(1):e12044. doi: 10.1002/dad2.12044. eCollection 2020.
Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD) and its associated dementia, warranting the development of strategies to improve early detection when prevention is possible.
Using a broad battery of neuropsychological assessments, informant interviews, and clinical record review, we evaluated the psychometrics of measures in a large sample of 561 adults with DS. We tracked longitudinal stability or decline in functioning in a subsample of 269 participants over a period of 3 years, all initially without indications of clinically significant aging-related decline.
Results identified an array of objective measures that demonstrated sensitivity in distinguishing individuals with incident "mild cognitive impairment" (MCI-DS) as well as subsequent declines occurring with incident dementia.
Several instruments showed clear promise for use as outcome measures for future clinical trials and for informing diagnosis of individuals suspected of experiencing early signs and symptoms of a progressive dementia process.
患有唐氏综合征（DS）的成年人患阿尔茨海默病（AD）及其相关痴呆症的风险很高，因此有必要制定策略，以便在可能预防的情况下改善早期检测。
我们使用一系列广泛的神经心理学评估、 informant访谈和临床记录审查，对561名患有DS的成年人大样本中的测量方法的心理测量学进行了评估。我们在269名参与者的子样本中跟踪了3年期间功能的纵向稳定性或下降情况，所有参与者最初均无临床显著的与年龄相关的下降迹象。
结果确定了一系列客观测量方法，这些方法在区分患有偶发性“轻度认知障碍”（MCI-DS）的个体以及偶发性痴呆症伴随的后续下降方面表现出敏感性。
几种工具显示出有望用作未来临床试验的结果测量方法，并为疑似经历进行性痴呆过程早期体征和症状的个体的诊断提供依据。
