Buxton B F, Tatoulis J, McNeil J J, Fuller J A
Epworth Private Hospital, Melbourne, Victoria, Australia.
J Cardiovasc Surg (Torino). 1988 Nov-Dec;29(6):633-8.
2,784 patients had a primary coronary artery reconstruction, between 1977 and 1987. From 1984, one internal mammary artery (IMA) and later both IMAs were used as the grafts of choice, supplemented where necessary with a saphenous vein graft (SVG). As a result, 1,681 patients had SVG, 726 had a single internal mammary artery graft (SIMA), while 377 patients had a bilateral internal mammary artery reconstruction (BIMA). Comparison of the pre-operative data showed that patients who had a SIMA were similar to those who had a SVG except that they were older, had a more stable presentation and they had a higher incidence of myocardial infarction. Patients who had a BIMA reconstruction were younger, more frequently male, presented with more stable symptoms, and had better left ventricular function than patients who had a SVG alone. Despite these favourable findings, the incidence of peri-operative myocardial infarction was higher in the BIMA group, compared with the SVG group. The change from SVG grafting to SIMA grafting was also associated with a higher incidence of post-operative bleeding. The surgical mortality was similar in all 3 groups. These findings suggest that the change to IMA grafting is associated with a slightly increased morbidity and perhaps this operation should be performed on selected patients rather than used routinely.
1977年至1987年间,2784例患者接受了初次冠状动脉重建术。从1984年起,一条乳内动脉(IMA),后来是两条乳内动脉被用作首选移植物,必要时辅以大隐静脉移植物(SVG)。结果,1681例患者使用了大隐静脉移植物,726例患者接受了单支乳内动脉移植物(SIMA),而377例患者接受了双侧乳内动脉重建术(BIMA)。术前数据比较显示,接受单支乳内动脉移植物的患者与接受大隐静脉移植物的患者相似,只是年龄更大,病情表现更稳定,心肌梗死发生率更高。接受双侧乳内动脉重建术的患者比仅接受大隐静脉移植物的患者更年轻,男性更常见,症状表现更稳定,左心室功能更好。尽管有这些有利发现,但与大隐静脉移植物组相比,双侧乳内动脉重建术组围手术期心肌梗死的发生率更高。从大隐静脉移植物移植改为单支乳内动脉移植物移植还与术后出血发生率较高有关。三组的手术死亡率相似。这些发现表明,改为乳内动脉移植物移植与发病率略有增加有关,也许这种手术应该在选定的患者中进行,而不是常规使用。