Barati Meisam, Jabbari Masoumeh, Nickho Hamid, Esparvarinha Mojgan, Javadi Mamaghani Amirreza, Majdi Hasan, Fathollahi Anwar, Davoodi Sayed Hossein
Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Cancer. 2021;73(6):956-967. doi: 10.1080/01635581.2020.1784442. Epub 2020 Jul 10.
This systematic review assesses the literature regarding beneficial and potential detrimental effects of bioactive peptides (BPs), focusing on evidence of regulatory T cells (T-regs) mediated oral tolerance (OT), collagen hydrolysate (CH) supplementation in osteoarthritis (OA) and the association of T-regs with chronic disease. The systematic search was done for articles published from inception to April 2019 using the PubMed and Scopus databases. About 3081 papers were identified by three different search strategies and screened against inclusion criteria which resulted in the inclusion of 22 articles. From the included articles, 12 papers were related to treatment of different disease in vivo by oral administration of BPs, six articles evaluated the effects of CH supplementation, as a rich source of BPs, on OA pain-relief and four observational studies assessed the association of circulating T-regs and risk of cancer and cardiovascular disease (CVD). The evidence obtained from first search strategy, indicated that oral administration of BPs improve clinical manifestations of animal models of allergy, arthritis, atherosclerosis, ulcerative colitis and allograft rejection by T-regs expansion; while, observational studies showed that although higher levels of circulating T-regs reduced risk of CVD and allergy, but, increased risk of solid cancers.
本系统评价评估了有关生物活性肽（BPs）有益和潜在有害作用的文献，重点关注调节性T细胞（T-regs）介导的口服耐受（OT）、骨关节炎（OA）中补充胶原蛋白水解物（CH）以及T-regs与慢性病之间关联的证据。使用PubMed和Scopus数据库对从创刊到2019年4月发表的文章进行了系统检索。通过三种不同的检索策略共识别出约3081篇论文，并根据纳入标准进行筛选，最终纳入22篇文章。在纳入的文章中，12篇论文涉及通过口服BPs在体内治疗不同疾病，6篇文章评估了作为BPs丰富来源的CH补充剂对OA疼痛缓解的作用，4项观察性研究评估了循环T-regs与癌症和心血管疾病（CVD）风险之间的关联。从首次检索策略中获得的证据表明，口服BPs可通过T-regs扩增改善过敏、关节炎、动脉粥样硬化、溃疡性结肠炎和同种异体移植排斥反应动物模型的临床表现；而观察性研究表明，虽然循环T-regs水平较高可降低CVD和过敏风险，但会增加实体癌风险。
