Parastouei Karim, Jabbari Masoumeh, Barati Meisam, Najafi Ali, Aryafar Maryam, Zeinalian Reihaneh, Rashidkhani Bahram
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran.
Department of Community Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran 1981619573, Iran.
Prev Nutr Food Sci. 2025 Aug 31;30(4):305-311. doi: 10.3746/pnf.2025.30.4.305.
This case-control study aimed to assess the association of dairy-derived digestion-resistant bioactive peptides (BPs) with the risk of prostate cancer (PCa) in a cohort of 50 men with PCa and 99 controls. Dietary, demographic, and anthropometric factors of all participants were assessed. Various types of dairy-derived BPs were determined by an method. High intake of total digestion-resistant BPs, low molecular weight peptides, high molecular weight peptides, phosphorylated residues, disulfide bonds, and antioxidant peptides was not significantly associated with the risk of PCa in the adjusted models (>0.05), while low-fat [odds ratio (OR): 0.19, 95% confidence intervals (CI): 0.05－0.66] and total dairy intake (OR: 0.23, 95% CI: 0.06－0.79) were inversely associated with PCa risk. To the best of our knowledge, this study is the first to report an association between dairy-derived BPs and the risk of PCa and an inverse association with consumption of dairy products in Iranian men likely due to the low intake of this population. Notably, the BP content of dairy products was not significantly associated with PCa risk.
这项病例对照研究旨在评估50名前列腺癌患者和99名对照组成的队列中，乳制品来源的抗消化生物活性肽（BPs）与前列腺癌（PCa）风险之间的关联。对所有参与者的饮食、人口统计学和人体测量学因素进行了评估。通过一种方法测定了各种类型的乳制品来源的BPs。在调整模型中，总抗消化BPs、低分子量肽、高分子量肽、磷酸化残基、二硫键和抗氧化肽的高摄入量与PCa风险无显著关联（>0.05），而低脂[比值比（OR）：0.19，95%置信区间（CI）：0.05－0.66]和总乳制品摄入量（OR：0.23，95%CI：0.06－0.79）与PCa风险呈负相关。据我们所知，本研究首次报道了乳制品来源的BPs与PCa风险之间的关联，以及伊朗男性中乳制品消费与PCa风险之间的负相关，这可能是由于该人群摄入量较低。值得注意的是，乳制品的BP含量与PCa风险无显著关联。
