Department of Cardiology, Shanghai Pudong Gongli Hospital, Shanghai 200135, China.
Biomark Med. 2020 Jun;14(9):739-747. doi: 10.2217/bmm-2019-0291. Epub 2020 Jul 10.
To clarify the diagnostic value of the circulating free fatty acid (FFA) level for acute myocardial infarction (AMI) in coronary heart disease patients. A total of 1776 patients were screened by coronary angiography from October 2014 to February 2016. The plasma FFA level was significantly higher in coronary heart disease patients with lesions in three or more vessels than those with lesions in one or two vessels. Moreover, an elevated FFA level was identified as an independent risk factor for AMI on multivariate regression analysis and shown to be a sensitive and specific indicator for AMI diagnosis by receiver operating characteristic curve analysis. An elevated FFA level is an independent risk factor and independent diagnostic marker for AMI.
为了明确循环游离脂肪酸（FFA）水平对冠心病患者急性心肌梗死（AMI）的诊断价值。 对 2014 年 10 月至 2016 年 2 月通过冠状动脉造影筛选出的 1776 例患者进行分析，结果显示，三支及以上病变患者的血浆 FFA 水平显著高于一支或两支病变患者。此外，多因素回归分析显示，FFA 水平升高是 AMI 的独立危险因素，ROC 曲线分析表明其是 AMI 诊断的敏感且特异的指标。 FFA 水平升高是 AMI 的独立危险因素和独立诊断标志物。
