Gruzdeva Olga, Uchasova Evgenya, Dyleva Yulia, Belik Ekaterina, Karetnikova Victoria, Shilov Alexander, Barbarash Olga
Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russia.
Lipids Health Dis. 2014 Jul 9;13:111. doi: 10.1186/1476-511X-13-111.
Free fatty acids (FFA), oxidized low-density lipoprotein (LDL) and its antibodies, lipid profile markers, which are formed under oxidative stress, play an important role in atherosclerotic disease. Assess the levels of these markers in myocardial infarction patients depending on the extent of coronary artery disease (CAD).
ST-elevation MI patients with hemodynamically significant stenoses of ≥ 75% in one, two, three, or more coronary arteries were examined. The patients were divided into three groups according to the severity of coronary lesions. Patients had a ≥ 75% stenotic lesion in one coronary artery (group 1, n=135), two coronary arteries (group 2, n=115), or three or more coronary arteries (group 3, n=150). The control group comprised healthy subjects (n=33).
FFA levels on day 1 from MI onset were higher in groups 1, 2, and 3 compared with controls. On day 1 from MI onset, oxidized LDL levels were significantly higher in groups 2 and 3 than those in controls (both р=0.001). Oxidized LDL levels were significantly higher in patients with multivessel CAD compared with those with single-vessel CAD on days 1 and 12. Antibody levels increased with the number of affected arteries.
High levels FFA, oxidized LDL and its antibody, lipid profile markers, and parameters of the pro/antioxidant systems persist during the subacute phase of MI.
游离脂肪酸（FFA）、氧化型低密度脂蛋白（LDL）及其抗体等脂质谱标志物在氧化应激状态下形成，在动脉粥样硬化疾病中起重要作用。根据冠状动脉疾病（CAD）的程度评估心肌梗死患者这些标志物的水平。
对单支、双支、三支或更多支冠状动脉存在血流动力学显著狭窄（≥75%）的ST段抬高型心肌梗死患者进行检查。根据冠状动脉病变的严重程度将患者分为三组。患者在单支冠状动脉存在≥75%的狭窄病变（第1组，n = 135）、双支冠状动脉（第2组，n = 115）或三支或更多支冠状动脉（第3组，n = 150）。对照组为健康受试者（n = 33）。
与对照组相比，第1组、第2组和第3组心肌梗死发病第1天的FFA水平更高。心肌梗死发病第1天，第2组和第3组的氧化型LDL水平显著高于对照组（p均 = 0.001）。在发病第1天和第12天，多支冠状动脉病变患者的氧化型LDL水平显著高于单支冠状动脉病变患者。抗体水平随受累动脉数量增加而升高。
在心肌梗死亚急性期，游离脂肪酸、氧化型LDL及其抗体、脂质谱标志物以及促氧化/抗氧化系统参数持续处于高水平。
