Tsutsumi Yoshinori, Iwano Shingo, Okumura Naoki, Adachi Shiro, Abe Shinji, Kondo Takahisa, Kato Katsuhiko, Naganawa Shinji
Radiology.
Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine, Aichi, Japan.
J Comput Assist Tomogr. 2020 Jul/Aug;44(4):578-585. doi: 10.1097/RCT.0000000000001052.
The objective of this study was to assess the correlation between dual-energy computed tomography quantitative parameters and hemodynamics in patients with chronic thromboembolic pulmonary hypertension.
Dual-energy computed tomography of 52 chronic thromboembolic pulmonary hypertension patients were evaluated retrospectively. The mean lung perfused blood volume (lung PBV) and the mean pulmonary artery (PA) enhancement measured at pulmonary parenchymal phase were compared with the hemodynamics by Spearman rank correlation coefficient (rs) and receiver operating characteristic analysis.
Lung PBV was correlated with mean pulmonary arterial pressure (rs = 0.47, P < 0.001). Pulmonary artery enhancement was correlated with cardiac index (rs = -0.49, P < 0.001) and pulmonary vascular resistance (rs = 0.48, P < 0.001). The areas under the curves were 0.86 for lung PBV to predict mean pulmonary arterial pressure of >50 mm Hg and 0.86 for PA enhancement to predict pulmonary vascular resistance of >1000 dyne·s/cm.
Lung PBV and PA enhancement could be indicators of hemodynamics.
本研究的目的是评估慢性血栓栓塞性肺动脉高压患者双能计算机断层扫描定量参数与血流动力学之间的相关性。
回顾性评估52例慢性血栓栓塞性肺动脉高压患者的双能计算机断层扫描。通过Spearman等级相关系数（rs）和受试者工作特征分析，将肺实质期测得的平均肺灌注血容量（肺PBV）和平均肺动脉（PA）强化与血流动力学进行比较。
肺PBV与平均肺动脉压相关（rs = 0.47，P < 0.001）。肺动脉强化与心脏指数相关（rs = -0.49，P < 0.001）和肺血管阻力相关（rs = 0.48，P < 0.001）。肺PBV预测平均肺动脉压>50 mmHg的曲线下面积为0.86，PA强化预测肺血管阻力>1000达因·秒/厘米的曲线下面积为0.86。
肺PBV和PA强化可能是血流动力学的指标。
