Biology Department, Boston University, Boston, MA 02215, USA.
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA.
Cell. 2020 Jul 9;182(1):24-37. doi: 10.1016/j.cell.2020.06.023.
Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
病毒基因组编码转录调节剂，改变病毒和宿主基因的表达。尽管在人类疾病中具有新兴作用，但目前缺乏对人类病毒转录调节剂 (vTR) 的全面注释，这限制了我们对其分子特征和功能的理解。在这里，我们提供了一个包含 20 种不同病毒家族的 419 种 vTR 的综合目录。使用这个目录，我们描述了特定 vTR 靶向的共有和独特的细胞基因、蛋白质和途径，并讨论了 vTR 在人类疾病发病机制中的作用。我们的研究为病毒学、基因组学和人类疾病遗传学领域提供了一个独特而有价值的资源。
