Chedid Pia, Salami Ali, El Shamieh Said
Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Balamand, Beirut 1100-2807, Lebanon.
Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V), Nabatieh 6573/14, Lebanon.
J Cardiovasc Dev Dis. 2020 Jul 8;7(3):24. doi: 10.3390/jcdd7030024.
Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension.
A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed.
We found that rs1898830 in was positively associated with hypertension (OR = 2.18, = 0.03) and negatively associated with high-density lipoprotein cholesterol (OR = 0.66, = 0.05). In contrast, no relation was found with total cholesterol and low-density lipoprotein cholesterol.
The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.
Toll样受体（TLRs）是天然免疫系统的重要组成部分，参与建立抗感染免疫。除了与免疫有关外，许多研究报告称，包括TLR2在内的许多TLRs参与了心血管疾病及其危险因素的发病机制。由于rs1898830与TLR2介导的细胞活化有关，我们旨在研究其与心血管疾病危险因素（如血脂水平和高血压）的关联。
对460名无慢性病个体进行横断面研究。收集临床和生物学数据，提取DNA并使用竞争性等位基因特异性PCR（KASP™）进行基因分型。使用调整了六个协变量的多重逻辑回归模型。还进行了功效计算分析。
我们发现rs1898830与高血压呈正相关（比值比=2.18，P=0.03），与高密度脂蛋白胆固醇呈负相关（比值比=0.66,P=0.05）。相比之下，未发现与总胆固醇和低密度脂蛋白胆固醇有关。
目前的结果提供了额外的证据，支持TLR2参与心血管疾病危险因素。
