遗传因素在急性呼吸道病毒感染COVID-19发展中的作用：预测严重病程及结局
The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes.
作者信息
Minashkin Mikhail M, Grigortsevich Nataliya Y, Kamaeva Anna S, Barzanova Valeriya V, Traspov Alexey A, Godkov Mikhail A, Ageev Farkhad A, Petrikov Sergey S, Pozdnyakova Nataliya V
机构信息
Sistema BioTech LLC, 109235 Moscow, Russia.
Clinical Laboratory, N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine, 129010 Moscow, Russia.
出版信息
Biomedicines. 2022 Feb 25;10(3):549. doi: 10.3390/biomedicines10030549.
The aim of this study was to identify single nucleotide variants in genes associated with susceptibility to or severe outcomes of COVID-19. A total of 319 genomic DNA samples from patients with varying degrees of disease severity and 78 control DNA samples from people who had regular or prolonged contact with patients with COVID-19 but did not have clinical manifestations and/or antibodies to SARS-CoV-2. Seven SNPs were identified that were statistically associated with disease risk or severe course, rs1799864 in the gene (OR = 2.21), rs1990760 in the gene (OR = 2.41), rs1800629 in the gene (OR = 1.98), rs75603675 in the gene (OR = 1.86), rs7842 in the gene (OR = 2.08), rs179008 in the gene (OR = 1.85), rs324011 in the gene (OR = 2.08), rs179008 in the gene (OR = 1.85), and rs324011 in the gene (OR = 1.84), as well as two variants associated with protection from COVID-19, rs744166 in the gene (OR = 0.36) and rs1898830 in the gene (OR = 0.47). The genotype in the region of these markers can be the criterion of the therapeutic approach for patients with COVID-19.
本研究的目的是鉴定与COVID-19易感性或严重后果相关基因中的单核苷酸变异。共收集了319份来自不同疾病严重程度患者的基因组DNA样本，以及78份来自与COVID-19患者有定期或长期接触但无临床表现和/或未感染SARS-CoV-2抗体的对照DNA样本。鉴定出7个与疾病风险或严重病程有统计学关联的单核苷酸多态性（SNP），分别为某基因中的rs1799864（比值比[OR]=2.21）、某基因中的rs1990760（OR=2.41）、某基因中的rs1800629（OR=1.98）、某基因中的rs75603675（OR=1.86）、某基因中的rs7842（OR=2.08）、某基因中的rs179008（OR=1.85）、某基因中的rs324011（OR=2.08），以及某基因中的rs179008（OR=1.85）和某基因中的rs324011（OR=1.84），还有两个与预防COVID-19相关的变异，分别为某基因中的rs744166（OR=0.36）和某基因中的rs1898830（OR=0.47）。这些标记区域的基因型可作为COVID-19患者治疗方法的标准。
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