Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China.
Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China
Biosci Rep. 2017 Oct 17;37(5). doi: 10.1042/BSR20170844. Print 2017 Oct 31.
Osteoarthritis (OA) is a complex disease that is induced by many genetic risk variants and other factors. To examine the role of toll-like receptor 9 (TLR-9) in OA patients, we conducted a case-control study involving 215 knee OA (KOA) patients and 215 controls in a Chinese population. Genotyping with a custom-by-design 48-Plex single nucleotide polymorphism Scan™ Kit showed the -9 gene rs187084 polymorphism was associated with an increased risk of KOA. Stratification analyses further validated this finding among old people (age ≥ 55 years). In conclusion, -9 gene rs187084 polymorphism is positively correlated with susceptibility to KOA, especially among old people. Nevertheless, this finding should be confirmed by larger size studies with more ethnic populations.
骨关节炎（OA）是一种复杂的疾病，由许多遗传风险变异和其他因素引起。为了研究 Toll 样受体 9（TLR-9）在 OA 患者中的作用，我们在中国人群中进行了一项病例对照研究，共纳入 215 例膝关节骨关节炎（KOA）患者和 215 名对照。使用定制的 48 plex 单核苷酸多态性扫描试剂盒进行基因分型显示，-9 基因 rs187084 多态性与 KOA 的发病风险增加相关。分层分析进一步验证了这一发现在老年人（年龄≥55 岁）中的作用。总之，-9 基因 rs187084 多态性与 KOA 的易感性呈正相关，尤其是在老年人中。然而，这一发现需要更大规模的、具有更多种族人群的研究来进一步证实。
