Department of Medical and Surgical Sciences and Advanced Technologies, "GF Ingrassia", University of Catania, 95123 Catania, Italy.
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Int J Mol Sci. 2020 Jul 8;21(14):4834. doi: 10.3390/ijms21144834.
Evidence suggests an association between an altered gut microbiota (dysbiosis), cognitive performance and behaviour. This paper provides an overview of the current literature regarding the cognitive-behavioural correlates of dysbiosis, with special attention on the clinical and biochemical mechanisms underlying the association between dysbiosis, cognition (mild cognitive impairment and dementia) and behaviour (depression, schizophrenia, addiction). After providing an overview of the evidence, the review discusses the molecular aspects that could account for the cognitive-behavioural correlates of dysbiosis. Shedding light on this topic could provide insights regarding the pathogenesis of these burdening neuropsychiatric disorders and even suggest future therapeutic strategies.
有证据表明，肠道微生物菌群（失调）的改变与认知表现和行为之间存在关联。本文综述了关于失调与认知（轻度认知障碍和痴呆）和行为（抑郁、精神分裂症、成瘾）之间关联的临床和生化机制的相关文献，特别关注了失调的认知-行为相关性。在提供了证据概述之后，本综述讨论了可以解释失调的认知-行为相关性的分子方面。阐明这个问题可以深入了解这些神经精神疾病的发病机制，甚至可以提出未来的治疗策略。
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