Sección de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Int J Mol Sci. 2020 Jul 8;21(14):4827. doi: 10.3390/ijms21144827.
Pulmonary arterial hypertension (PAH) is a severe disease characterized by the loss and obstructive remodeling of the pulmonary arterial wall, causing a rise in pulmonary arterial pressure and pulmonary vascular resistance, which is responsible for right heart failure, functional decline, and death. Although many drugs are available for the treatment of this condition, it continues to be life-threatening, and its long-term treatment is expensive. On the other hand, many natural compounds present in food have beneficial effects on several cardiovascular conditions. Several studies have explored many of the potential beneficial effects of natural plant products on PAH. However, the mechanisms by which natural products, such as nutraceuticals, exert protective and therapeutic effects on PAH are not fully understood. In this review, we analyze the current knowledge on nutraceuticals and their potential use in the protection and treatment of PAH, as well as whether nutraceuticals could enhance the effects of drugs used in PAH through similar mechanisms.
肺动脉高压（PAH）是一种严重的疾病，其特征是肺动 脉壁的丧失和阻塞性重塑，导致肺动脉压和肺血管阻力升高，从而导致右心衰竭、功能下降和死亡。尽管有许多药物可用于治疗这种疾病，但它仍然具有致命性，长期治疗费用昂贵。另一方面，食物中存在的许多天然化合物对多种心血管疾病都有有益的影响。许多研究已经探讨了许多天然植物产品对 PAH 的潜在有益作用。然而，天然产物（如营养保健品）对 PAH 发挥保护和治疗作用的机制尚不完全清楚。在这篇综述中，我们分析了营养保健品的现有知识及其在 PAH 的保护和治疗中的潜在用途，以及营养保健品是否可以通过类似的机制增强用于 PAH 的药物的效果。
