Abhinav Rajendra Prabhu, Williams Joanne, Livingston Patricia, Anjana Ranjit Mohan, Mohan Viswanathan
School of Health and Social Development, Deakin University, Geelong, Victoria, Australia; Madras Diabetes Research Foundation, Chennai, India.
School of Health and Social Development, Deakin University, Geelong, Victoria, Australia.
J Diabetes Complications. 2020 Nov;34(11):107670. doi: 10.1016/j.jdiacomp.2020.107670. Epub 2020 Jul 2.
Oral cancer and diabetes are highly prevalent among the Indian population and are part of the top four non-communicable diseases responsible for mortality and morbidity. Their numbers are so great that they pose a unique burden to the socioeconomic growth of the country. In recent years, there has been an increase in the number of studies examining the role of diabetes in oral cancer reporting co-existence of diabetes and cancer. There is also growing evidence of a higher risk for developing a number of cancers among individuals with diabetes, including pancreatic, liver, gynecologic, colorectal, oral and breast cancer, and consequently 'diabetic oncopathy' is emerging as one of the complications of diabetes. Diabetes may lead to the development of cancer through oxidative damage leading to accumulation of DNA mutations and/or through immune dysfunction, which predisposes to viral infection. Cancer and diabetes may co-occur due to shared risk factors such as increased insulin-like growth factor-1 and obesity, but there is no clear biologic link between the two disorders. This literature review aims to review the evidence showing the current burden of two non-communicable diseases, diabetes and oral cancer and their potential association, with particular reference to India.
口腔癌和糖尿病在印度人群中极为普遍，是导致死亡和发病的四大非传染性疾病的一部分。它们的数量如此之多，给该国的社会经济增长带来了独特的负担。近年来，研究糖尿病在口腔癌中作用（报告糖尿病与癌症并存情况）的研究数量有所增加。越来越多的证据表明，糖尿病患者患多种癌症的风险更高，包括胰腺癌、肝癌、妇科癌症、结直肠癌、口腔癌和乳腺癌，因此“糖尿病性肿瘤病变”正成为糖尿病的并发症之一。糖尿病可能通过导致DNA突变积累的氧化损伤和/或通过免疫功能障碍导致癌症的发生，而免疫功能障碍易引发病毒感染。癌症和糖尿病可能由于胰岛素样生长因子-1增加和肥胖等共同风险因素而同时出现，但这两种疾病之间没有明确的生物学联系。这篇文献综述旨在回顾表明糖尿病和口腔癌这两种非传染性疾病当前负担及其潜在关联的证据，特别提及印度。
