Washington Institute of Dermatologic Laser Surgery, 1430 K St NW, Suite 200, Washington, DC, 20005, USA.
Am J Clin Dermatol. 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0.
Botulinum toxin type A (BoNTA) is a powerful neurotoxin that inhibits acetylcholine release from presynaptic vesicles. The potency and safety profile of BoNTA grant the toxin vast therapeutic potential. It has been used off-label for a variety of dermatologic conditions. This review aims to analyze published literature regarding the benefits and risks of the off-label use of BoNTA beyond facial lines, including eccrine hidrocystomas, enlarged pores, keloids and hypertrophic scars, hidradenitis suppurativa, hyperhidrosis, masseter muscle hypertrophy, and salivary gland hypertrophy, among others. A MEDLINE search from January 2000 to December 2019 was conducted on the off-label uses of botulinum toxin in dermatology.
A型肉毒毒素（BoNTA）是一种强大的神经毒素，可抑制突触前囊泡中乙酰胆碱的释放。BoNTA 的效力和安全性使其具有广泛的治疗潜力。它已被超适应证用于多种皮肤科疾病。本综述旨在分析已发表的文献，探讨 BoNTA 在除面部皱纹以外的适应证中的获益和风险，包括小汗腺汗囊瘤、毛孔粗大、瘢痕疙瘩和增生性瘢痕、化脓性汗腺炎、多汗症、咬肌肥大和唾液腺肥大等。对 2000 年 1 月至 2019 年 12 月在皮肤科应用 BoNTA 的超适应证治疗进行了 MEDLINE 检索。
