SARS-CoV-2 依赖 ACE2 的内分泌学意义。
Endocrine Significance of SARS-CoV-2's Reliance on ACE2.
机构信息
Department of Pharmacology & Experimental Therapeutics, New Orleans, Louisiana.
Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
出版信息
Endocrinology. 2020 Sep 1;161(9). doi: 10.1210/endocr/bqaa108.
The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.
当前的 COVID-19 大流行是过去 50 年来最具破坏性的事件，对全球医疗保健和世界经济都产生了影响。它是由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的，这是一种冠状病毒，使用血管紧张素转换酶 2（ACE2）作为进入细胞的切入点。ACE2 是一种跨膜羧肽酶，是肾素-血管紧张素系统的成员。这篇简要综述总结了 ACE2 在内分泌组织中的表达和功能的主要发现。我们讨论了 ACE2 和 SARS 冠状病毒在内分泌学和糖尿病、性腺功能减退、垂体和甲状腺疾病发展中的潜在作用的快速发展的知识。
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