[左旋咪唑对慢性布鲁氏菌病患者细胞免疫及体液免疫指标的影响]
[Effect of levamisole on the cellular and humoral immunity indices in patients with chronic brucellosis].
作者信息
Mukovozova L A
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1988 Oct(10):45-9.
In chronic brucellosis patients receiving levamisole and placebo the dynamics of quantitative and functional characteristics of cell-mediated and humoral immunity have been studied. The immunomodulating effect of levamisole, manifested only in the process of treatment by a rise in the number of circulating lymphoid cells, their functional capacity, a decrease in the disproportion of immunoregulatory cells and the amount of circulating immune complexes, has been established. The positive dynamics of immunological characteristics have been found to improve both immediate and remote results of the clinical effectiveness of levamisole.
对接受左旋咪唑和安慰剂治疗的慢性布鲁氏菌病患者的细胞介导免疫和体液免疫的定量及功能特征动态变化进行了研究。已证实左旋咪唑的免疫调节作用仅在治疗过程中表现为循环淋巴细胞数量增加、其功能能力增强、免疫调节细胞比例失衡减轻以及循环免疫复合物量减少。已发现免疫特征的积极动态变化可改善左旋咪唑临床疗效的近期和远期结果。
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