胃癌高表达转录本 1 的异常表达是人类癌症的诊断和预后生物标志物。

Aberrant Expression of Gastric Carcinoma High Expressed Transcript 1 is a Diagnostic and Prognostic Biomarker in Human Cancer.

机构信息

School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, PR China.

Department of Cardiology, Jilin Provincial People's Hospital, 1183 Gongnong Road, Changchun, Jilin, 130033, PR China.

出版信息

J Natl Med Assoc. 2020 Dec;112(6):602-612. doi: 10.1016/j.jnma.2020.05.017. Epub 2020 Jul 9.

DOI:10.1016/j.jnma.2020.05.017

PMID:32653201

Abstract

BACKGROUND

Gastric carcinoma high expressed transcript 1 (GHET1), a long noncoding RNA (LncRNA), has been reported to be involved in tumor genesis and cancer progression. High GHET1 expression is correlated with a poor prognosis in cancer. In this meta-analysis, we investigated the association between GHET1 and lymph node metastasis, differentiation, vascular invasion and so on in human cancer.

METHODS

We performed systematic search in PubMed, EMBASE, Wiley Online Library, Wiley Online Library, and Medline from January 1, 1996 to September 25, 2017. A total of 8 studies were selected for further research.

RESULTS

The result showed that GHET1 expression was significantly associated with OS (hazard ratio [HR] = 2.23; 95% CI, 1.86-2.67; P < 0.0001), including digestive system tumor (HR = 2.17; 95% CI, 1.63-2.89; P < 0.0001). Moreover, high GHET1 expression was related to tumor size (odds ratio [OR] = 2.15, 95% CI: 1.57-2.94; P < 0.00001), TNM stage (Ⅲ+Ⅳ vs.Ⅰ+Ⅱ; OR = 4.02, 95% CI:3.06-5.28; P < 0.00001), lymph node metastasis (Yes vs. No; OR = 3.55, 95% CI:2.54-4.95; P < 0.00001), differentiation (poor vs. well or moderate; OR = 1.72, 95% CI:1.22-2.42; P = 0.002), vascular invasion (Yes vs. No; OR = 3.03, 95% CI:1.80-5.12; P = 0.00001). Also, we found that high expression of GHET1 has a significant relationship with analysis method and sample size. It almost higher in different human cancers.

CONCLUSIONS

GHET1 may serve as a potential clinical biomarker and poor survival and high-risk recurrence in cancers.

摘要

背景

胃癌高表达转录本 1（GHET1）是一种长链非编码 RNA（lncRNA），已被报道参与肿瘤发生和癌症进展。GHET1 高表达与癌症预后不良相关。在这项荟萃分析中，我们研究了 GHET1 与人类癌症中的淋巴结转移、分化、血管侵犯等之间的关系。

方法

我们在 PubMed、EMBASE、Wiley Online Library、Wiley Online Library 和 Medline 上进行了系统检索，检索时间为 1996 年 1 月 1 日至 2017 年 9 月 25 日。共有 8 项研究符合进一步研究的条件。

结果

结果表明，GHET1 表达与 OS 显著相关（风险比[HR] = 2.23；95% CI，1.86-2.67；P < 0.0001），包括消化系统肿瘤（HR = 2.17；95% CI，1.63-2.89；P < 0.0001）。此外，GHET1 高表达与肿瘤大小（比值比[OR] = 2.15，95% CI：1.57-2.94；P < 0.00001）、TNM 分期（Ⅲ+Ⅳ vs.Ⅰ+Ⅱ；OR = 4.02，95% CI：3.06-5.28；P < 0.00001）、淋巴结转移（是 vs. 否；OR = 3.55，95% CI：2.54-4.95；P < 0.00001）、分化（差 vs. 好或中；OR = 1.72，95% CI：1.22-2.42；P = 0.002）、血管侵犯（是 vs. 否；OR = 3.03，95% CI：1.80-5.12；P = 0.00001）有关。此外，我们发现 GHET1 的高表达与分析方法和样本量有显著关系。在不同的人类癌症中，它几乎更高。