• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

GHEGT1 作为一个预后指标，并作为一个癌基因 lncRNA 在宫颈癌中发挥作用。

GHET1 acts as a prognostic indicator and functions as an oncogenic lncRNA in cervical cancer.

机构信息

Department of Gynaecology and Obstetrics, Xian XD Group Hospital, Xi'an 710077, Shanxi, China.

Department of Gynaecology and Obstetrics, Affiliated Huxi Hospital of Jining Medical College, Shanxian County, Heze 274300, Shandong, China.

出版信息

Biosci Rep. 2019 Apr 30;39(4). doi: 10.1042/BSR20182506.

DOI:10.1042/BSR20182506
PMID:30948501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6488859/
Abstract

Gastric carcinoma proliferation enhancing transcript 1 (GHET1) has been suggested to serve as a promising oncogenic lncRNA in various types of human cancer. However, the role of GHET1 remained unknown in cervical cancer. In our study, we found GHET1 expression was markedly elevated in cervical cancer tissue specimens and cell lines compared with adjacent normal cervical tissue specimens and human normal cervical cell line, respectively. Then, we found high expression of GHET1 is a useful biomarker to discriminate cervical cancer tissues from non-tumorous tissues, and associated with advanced clinical stage, lymph node metastasis, distant metastasis and poor histological grade in cervical cancer patients. The survival analysis showed high GHET1 expression was an independent unfavorable prognostic factor in cervical cancer patients. Knockdown of GHET1 expression markedly inhibits cervical cancer cell proliferation, migration, and invasion. The loss-of-function study indicated knockdown of GHET1 expression markedly inhibits cervical cancer cell proliferation, migration, and invasion. In conclusion, GHET1 acts as an oncogenic lncRNA in cervical cancer.

摘要

胃腺癌增殖增强转录本 1（GHET1）已被认为是多种人类癌症中一种有前途的致癌 lncRNA。然而，GHET1 在宫颈癌中的作用尚不清楚。在我们的研究中，我们发现与相邻的正常宫颈组织标本和人正常宫颈细胞系相比，GHET1 在宫颈癌组织标本和细胞系中的表达明显升高。然后，我们发现 GHET1 的高表达是区分宫颈癌组织与非肿瘤组织的有用生物标志物，并且与宫颈癌患者的晚期临床分期、淋巴结转移、远处转移和不良组织学分级相关。生存分析显示，GHET1 高表达是宫颈癌患者的独立不良预后因素。敲低 GHET1 的表达显著抑制宫颈癌细胞的增殖、迁移和侵袭。功能丧失研究表明，敲低 GHET1 的表达显著抑制宫颈癌细胞的增殖、迁移和侵袭。总之，GHET1 在宫颈癌中作为一种致癌 lncRNA 发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/7659e48ce18d/bsr-39-bsr20182506-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/d5f629ca2674/bsr-39-bsr20182506-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/50405c48cc7f/bsr-39-bsr20182506-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/5541214bc332/bsr-39-bsr20182506-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/7659e48ce18d/bsr-39-bsr20182506-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/d5f629ca2674/bsr-39-bsr20182506-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/50405c48cc7f/bsr-39-bsr20182506-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/5541214bc332/bsr-39-bsr20182506-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a49/6488859/7659e48ce18d/bsr-39-bsr20182506-g4.jpg

相似文献

1
GHET1 acts as a prognostic indicator and functions as an oncogenic lncRNA in cervical cancer.GHEGT1 作为一个预后指标，并作为一个癌基因 lncRNA 在宫颈癌中发挥作用。
Biosci Rep. 2019 Apr 30;39(4). doi: 10.1042/BSR20182506.
2
Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.敲低 lncRNA GHET1 抑制骨肉瘤细胞在体外和体内的增殖、侵袭、迁移和 EMT。
Cancer Biomark. 2018;23(4):589-601. doi: 10.3233/CBM-181863.
3
LINC00511 is associated with the malignant status and promotes cell proliferation and motility in cervical cancer.LINC00511 与恶性状态相关，并促进宫颈癌中的细胞增殖和迁移。
Biosci Rep. 2019 Sep 13;39(9). doi: 10.1042/BSR20190903. Print 2019 Sep 30.
4
Long non-coding RNA GHET1 promotes human breast cancer cell proliferation, invasion and migration via affecting epithelial mesenchymal transition.长非编码 RNA GHET1 通过影响上皮间质转化促进人乳腺癌细胞的增殖、侵袭和迁移。
Cancer Biomark. 2018;22(3):565-573. doi: 10.3233/CBM-181250.
5
Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers.LncRNA GHET1 的过表达预示着各种癌症患者的生存状况和临床参数不佳。
J Cell Mol Med. 2019 Aug;23(8):4891-4899. doi: 10.1111/jcmm.14486. Epub 2019 Jun 28.
6
LncRNA GHET1 promotes esophageal squamous cell carcinoma cells proliferation and invasion via induction of EMT.长链非编码RNA GHET1通过诱导上皮-间质转化促进食管鳞状细胞癌细胞的增殖和侵袭。
Int J Biol Markers. 2017 Oct 31;32(4):e403-e408. doi: 10.5301/ijbm.5000304.
7
LncRNA GHET1 predicts poor prognosis in hepatocellular carcinoma and promotes cell proliferation by silencing KLF2.长链非编码 RNA GHET1 预测肝细胞癌预后不良，并通过沉默 KLF2 促进细胞增殖。
J Cell Physiol. 2018 Jun;233(6):4726-4734. doi: 10.1002/jcp.26257. Epub 2017 Dec 26.
8
Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer.lncRNA GAS5表达降低预示宫颈癌预后不良。
Int J Clin Exp Pathol. 2014 Sep 15;7(10):6776-83. eCollection 2014.
9
LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways.长链非编码 RNA GHET1 通过调控 AKT/mTOR 和 Wnt/β-连环蛋白信号通路促进宫颈癌的进展。
Biosci Rep. 2020 Jan 31;40(1). doi: 10.1042/BSR20191265.
10
Prognostic significance of LncRNA GHET1 expression in various cancers: a systematic review and meta-analysis.LncRNA GHET1 表达在多种癌症中的预后意义：系统评价和荟萃分析。
Biosci Rep. 2019 Oct 30;39(10). doi: 10.1042/BSR20190608.

引用本文的文献

1
Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer.长链非编码RNA作为宫颈癌中有前景的生物标志物和治疗靶点。
Noncoding RNA Res. 2023 Feb 21;8(2):233-239. doi: 10.1016/j.ncrna.2023.02.006. eCollection 2023 Jun.
2
Long non-coding RNA GHET1 promotes thyroid cancer cell proliferation and invasion.长链非编码RNA GHET1促进甲状腺癌细胞的增殖和侵袭。
Transl Cancer Res. 2021 Sep;10(9):4148-4157. doi: 10.21037/tcr-21-1615.
3
A Prognostic Model Based on Immune-Related Long Non-Coding RNAs for Patients With Cervical Cancer.

本文引用的文献

1
Chemotherapy and molecular therapy in cervical cancer.宫颈癌的化疗与分子治疗
Rep Pract Oncol Radiother. 2018 Nov-Dec;23(6):533-539. doi: 10.1016/j.rpor.2018.09.002. Epub 2018 Sep 27.
2
Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.敲低 lncRNA GHET1 抑制骨肉瘤细胞在体外和体内的增殖、侵袭、迁移和 EMT。
Cancer Biomark. 2018;23(4):589-601. doi: 10.3233/CBM-181863.
3
Long noncoding RNA GHET1 in human cancer.长链非编码 RNA GHET1 在人类癌症中的作用。
一种基于免疫相关长链非编码RNA的宫颈癌患者预后模型。
Front Pharmacol. 2020 Nov 30;11:585255. doi: 10.3389/fphar.2020.585255. eCollection 2020.
4
A novel mechanism by which ACTA2-AS1 promotes cervical cancer progression: acting as a ceRNA of miR-143-3p to regulate SMAD3 expression.ACTA2-AS1促进宫颈癌进展的一种新机制：作为miR-143-3p的竞争性内源RNA调节SMAD3表达。
Cancer Cell Int. 2020 Aug 5;20:372. doi: 10.1186/s12935-020-01471-w. eCollection 2020.
5
lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer.长链非编码 RNA OIP5-AS1 通过靶向 ROCK1 并作用于 miR-143-3p 促进宫颈癌的细胞增殖并抑制细胞凋亡。
Braz J Med Biol Res. 2020 Jan 13;53(1):e8883. doi: 10.1590/1414-431X20198883. eCollection 2020.
6
Long Noncoding RNA Can Be a Probable Mechanism and a Novel Target for Diagnosis and Therapy in Fragile X Syndrome.长链非编码RNA可能是脆性X综合征诊断和治疗的一种机制及新靶点。
Front Genet. 2019 May 22;10:446. doi: 10.3389/fgene.2019.00446. eCollection 2019.
Clin Chim Acta. 2019 Jan;488:111-115. doi: 10.1016/j.cca.2018.11.007. Epub 2018 Nov 3.
4
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
5
lncRNA GHET1 down-regulation suppresses the cell activities of glioma.长链非编码 RNA GHET1 的下调抑制了神经胶质瘤细胞的活性。
Cancer Biomark. 2018;23(1):9-22. doi: 10.3233/CBM-171002.
6
Long non-coding RNA GHET1 promotes human breast cancer cell proliferation, invasion and migration via affecting epithelial mesenchymal transition.长非编码 RNA GHET1 通过影响上皮间质转化促进人乳腺癌细胞的增殖、侵袭和迁移。
Cancer Biomark. 2018;22(3):565-573. doi: 10.3233/CBM-181250.
7
LncRNA GHET1 predicts a poor prognosis of the patients with non-small cell lung cancer.长链非编码 RNA GHET1 预测非小细胞肺癌患者的预后不良。
Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2328-2333. doi: 10.26355/eurrev_201804_14823.
8
Long non-coding RNA gastric carcinoma highly expressed transcript 1 promotes cell proliferation and invasion in human head and neck cancer.长链非编码RNA胃癌高表达转录本1促进人头颈癌细胞增殖和侵袭。
Oncol Lett. 2018 May;15(5):6941-6946. doi: 10.3892/ol.2018.8185. Epub 2018 Mar 7.
9
Cancer incidence and mortality in China, 2014.2014年中国的癌症发病率和死亡率
Chin J Cancer Res. 2018 Feb;30(1):1-12. doi: 10.21147/j.issn.1000-9604.2018.01.01.
10
Cancer statistics, 2018.癌症统计数据，2018 年。
CA Cancer J Clin. 2018 Jan;68(1):7-30. doi: 10.3322/caac.21442. Epub 2018 Jan 4.