Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea.
Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea; Department of Systems Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea.
Int J Biol Macromol. 2020 Nov 15;163:824-832. doi: 10.1016/j.ijbiomac.2020.07.071. Epub 2020 Jul 10.
In this study, multifunctional hydrogels containing host-guest complex formation between azobenzene-grafted carboxymethyl cellulose (CMC-Azo) and β-cyclodextrin (CD) dimers connected by disulfide bonds with agarose for structural support were prepared. The obtained hydrogels exhibited self-healing properties by host-guest complexation as well as gel-sol phase transition in response to ultraviolet (UV) light and reducing agents. Photo-switchable properties of the hydrogels depend on changes in the complex formation of CD-dimers through the trans(450 nm) to cis(365 nm) photo-isomerization of azobenzene. The tensile and strain sweep tests confirmed that the hydrogel's self-healing ability was 79.44% and 81.59%, respectively. In addition, drug release from the hydrogels was controlled to accelerate to 80% in 3 h using UV light or reducing agent. Since the suggested photo-switchable, reduction-responsive, and self-healable hydrogels are non-cytotoxic, they can be potentially applied as biomedical materials in the development of hydrogel-based drug release systems.
在这项研究中，制备了含有通过二硫键连接的偶氮苯接枝羧甲基纤维素（CMC-Azo）和β-环糊精（CD）二聚体的主体-客体复合形成的多功能水凝胶，琼脂糖作为结构支撑。所得水凝胶通过主体-客体络合以及对紫外（UV）光和还原剂的凝胶-溶胶相转变表现出自修复性能。水凝胶的光致变色性能取决于通过偶氮苯的反式（450nm）到顺式（365nm）光异构化，使 CD-二聚体的络合形成发生变化。拉伸和应变扫描测试证实水凝胶的自修复能力分别为 79.44%和 81.59%。此外，使用紫外光或还原剂将水凝胶的药物释放控制在 3 小时内加速至 80%。由于所提出的光致变色、还原响应和自修复水凝胶是非细胞毒性的，因此它们可作为基于水凝胶的药物释放系统的生物医学材料进行开发。
