School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
Sci Total Environ. 2020 Nov 15;743:140678. doi: 10.1016/j.scitotenv.2020.140678. Epub 2020 Jul 6.
Environmental phenols, bisphenol A (BPA), triclosan (TCS), and benzophenone-3 (BP-3), are known as emerging endocrine-disrupting chemicals; however, their impacts on thyroid hormones and children's neurobehaviors are still unclear.
We aimed to examine the associations of prenatal and childhood exposure to phenols with neonatal thyroid function and childhood behavioral problems aged 10 years.
A total of 386 mother-singleton pairs were included from Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. We quantified urinary BPA, TCS and BP-3 concentrations in maternal and 10-year-old children's urine samples using gas chromatography tandem mass spectrometry and thyroid function parameters in cord serum samples. Caregivers completed the Strength and Difficulties Questionnaire (SDQ) for their children at 10 years of age. Multivariable linear regression models and logistic regression models were applied to estimate associations of urinary phenol concentrations with thyroid hormones and risks of children's behavioral problems, respectively.
The median values of urinary BPA, TCS and BP-3 concentrations for pregnant women were 1.75 μg/L, 0.54 μg/L and 0.37 μg/L, while 1.29 μg/L, 6.64 μg/L and 1.39 μg/L for children, respectively. Maternal urinary BPA concentrations were in associations with 1.00% [95% confidence interval (CI): 0.20%, 1.92%] increases in cord serum FT4 concentrations and significantly associated with increased risks of total difficulties [odds ratio (OR): 1.45, 95% CI: 1.07, 1.97], while maternal urinary levels of BP-3 were significantly related to poorer prosocial behaviors (OR: 1.58, 95% CI: 1.04, 2.39) of children at 10 years of age. In sex-stratified analyses, maternal urinary BPA concentrations were related to increased total difficulty subscales only in boys.
The findings indicated that higher prenatal urinary BPA concentrations were associated with increased risks of total difficulties, especially in boys and maternal urinary BP-3 concentrations were related to poorer prosocial behaviors at 10 years.
环境酚类、双酚 A（BPA）、三氯生（TCS）和二苯甲酮-3（BP-3）被认为是新兴的内分泌干扰化学物质；然而，它们对甲状腺激素和儿童神经行为的影响尚不清楚。
本研究旨在探讨产前和儿童时期接触酚类物质与新生儿甲状腺功能和 10 岁儿童行为问题的关系。
本研究纳入了来自射阳母婴队列研究（SMBCS）的 386 对母婴对子，这是一项在中国开展的纵向母婴队列研究。我们使用气相色谱-串联质谱法测定了母亲和 10 岁儿童尿液样本中的 BPA、TCS 和 BP-3 浓度，并检测了脐带血清样本中的甲状腺功能参数。10 岁时，儿童的照顾者完成了长处和困难问卷（SDQ）。多变量线性回归模型和逻辑回归模型分别用于估计尿液酚浓度与甲状腺激素和儿童行为问题风险之间的关系。
孕妇尿液中 BPA、TCS 和 BP-3 的中位数浓度分别为 1.75μg/L、0.54μg/L 和 0.37μg/L，儿童尿液中分别为 1.29μg/L、6.64μg/L 和 1.39μg/L。孕妇尿液中的 BPA 浓度与脐带血清 FT4 浓度升高 1.00%[95%置信区间（CI）：0.20%，1.92%]相关，与总困难风险显著增加相关[比值比（OR）：1.45，95%CI：1.07，1.97]，而母亲尿液中 BP-3 水平与 10 岁儿童亲社会行为较差显著相关（OR：1.58，95%CI：1.04，2.39）。在按性别分层分析中，母亲尿液中的 BPA 浓度仅与男孩的总困难亚量表升高有关。
这些发现表明，较高的产前尿液 BPA 浓度与总困难风险增加有关，尤其是男孩，而母亲尿液中的 BP-3 浓度与 10 岁儿童的亲社会行为较差有关。
