Department of Nursing, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
Department of Geriatric, Quanzhou First Hospital Affiliated To Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian, China.
Clin Exp Med. 2020 Nov;20(4):527-533. doi: 10.1007/s10238-020-00644-1. Epub 2020 Jul 11.
Venous thromboembolism (VTE) is a common complication of colon cancer. In the present study, we aimed to explore the association of the oncogene COX7C to VTE in colon cancer patients. Samples from 580 patients were examined histologically for VTE and pathological characteristic of cancer. Gene mutation and expression analysis were performed using polymerase chain reaction-based assays to evaluate genes related to VTE, including COX7C. Univariate analysis between clinical pathological factors and VTE was conducted. Logistic regression analysis was performed for the prediction of VTE by pathological factors and gene expressions. Among patients investigated, a total of 56 patients had VTE. COX7C had a significant correlation with VTE (p < 0.001). Despite a correlation between tumor size, invasion depth of tumor, lymph node metastasis, lymph node metastasis, distant metastasis, lymphovascular invasion, histologic type and pathology type, Ki-67, and some other genes, to VTE (p > 0.05), only COX7C expression demonstrated significance in its ability to predict VTE. Here, we show that COX7C upregulation strongly correlates with VTE in colon cancer, which implicates its role as a biomarker and therapeutic target of VTE in colon cancer.
静脉血栓栓塞症（VTE）是结肠癌的常见并发症。在本研究中，我们旨在探讨癌基因 COX7C 与结肠癌患者 VTE 的关系。对 580 例患者的样本进行组织学检查以确定 VTE 以及癌症的病理特征。使用聚合酶链反应（PCR）检测方法进行基因突变和表达分析，以评估与 VTE 相关的基因，包括 COX7C。对临床病理因素与 VTE 之间的关系进行单因素分析。对病理因素和基因表达进行逻辑回归分析以预测 VTE。在调查的患者中，共有 56 例发生 VTE。COX7C 与 VTE 显著相关（p<0.001）。尽管肿瘤大小、肿瘤浸润深度、淋巴结转移、远处转移、淋巴管浸润、组织学类型和病理类型、Ki-67 以及其他一些基因与 VTE 之间存在相关性（p>0.05），但只有 COX7C 表达在预测 VTE 方面具有显著意义。我们的研究结果表明，COX7C 的上调与结肠癌中的 VTE 密切相关，这表明它可能是结肠癌 VTE 的生物标志物和治疗靶点。
