严重急性 SARS-CoV-2 感染患者中非经典和中间单核细胞亚群减少。
Decrease of Non-Classical and Intermediate Monocyte Subsets in Severe Acute SARS-CoV-2 Infection.
机构信息
Hematology Laboratory and Transfusion Center, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.
Department of Intensive Care, Western Milan Area Hospital Consortium, Legnano General Hospital, Milan, Italy.
出版信息
Cytometry A. 2020 Sep;97(9):887-890. doi: 10.1002/cyto.a.24188. Epub 2020 Aug 14.
Abstract
In patients with severe SARS-CoV-2 infection, the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non-classical (NC) and intermediate (INT) monocytes are known to be involved during viral and bacterial infections. In this study, 30 patients with different manifestations of acute SARS-CoV-2 infection were investigated with a flow cytometric study of NC, INT, and classical (CL) monocytes. Significantly reduced NC and INT monocytes and a downregulated HLA-DR were found in acute patients with severe SARS-CoV-2 symptoms. Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. © 2020 International Society for Advancement of Cytometry.
摘要
在严重的 SARS-CoV-2 感染患者中，细胞因子风暴的发展导致广泛的肺部损伤，单核细胞在这一病理过程中发挥作用。众所周知，非经典（NC）和中间（INT）单核细胞在病毒和细菌感染过程中参与其中。在这项研究中，通过流式细胞术研究 NC、INT 和经典（CL）单核细胞，对 30 名具有不同急性 SARS-CoV-2 感染表现的患者进行了调查。在严重 SARS-CoV-2 症状的急性患者中，发现 NC 和 INT 单核细胞以及 HLA-DR 显著减少。相反，在症状中等的患者中，NC 和 INT 单核细胞和 CD11b 表达增加。
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