采用气相色谱法测定人血浆中的抗惊厥药物——丙戊酸乙酯（德巴金）。
Determination of the anticonvulsant drug--dipropyl acetate (Epilim) in human plasma by gas chromatography.
作者信息
U-Schulz H, Toseland P A
出版信息
Ann Clin Biochem. 1977 Jul;14(4):240-2. doi: 10.1177/000456327701400164.
PMID:332044
Abstract
A relatively simple gas chromatographic procedure is proposed for the analysis of the drug dipropylacetic acid in plasma. The compound is chromatographed, as the free acid after ether extraction. Prior to concentration of the solvent the acid is converted to its potassium salt, then regenerated to the free acid immediately before analysis.
摘要
提出了一种相对简单的气相色谱法用于分析血浆中的药物双丙戊酸。该化合物经乙醚萃取后以游离酸形式进行色谱分析。在浓缩溶剂之前，将酸转化为其钾盐，然后在分析前立即再生为游离酸。
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引用本文的文献
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Valproic acid and diazepam interaction in vivo.丙戊酸与地西泮的体内相互作用。
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Decreased plasma protein binding of phenytoin in patients on valproic acid.丙戊酸治疗的患者中苯妥英的血浆蛋白结合率降低。
Br J Clin Pharmacol. 1979 Dec;8(6):547-52. doi: 10.1111/j.1365-2125.1979.tb01042.x.
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Lack of hepatic enzyme inducing effect of sodium valproate.丙戊酸钠缺乏肝酶诱导作用。
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Disposition of sodium valproate in epileptic patients.丙戊酸钠在癫痫患者体内的处置情况。
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