Leviel V, Naquet R
Epilepsia. 1977 Jun;18(2):229-34. doi: 10.1111/j.1528-1157.1977.tb04470.x.
The effect of an antiepileptic drug, valproic acid (VPA), on an experimental form of epilepsy, the kindling phenomenon, is described. In cat, 50 mg/kg i.p. per day is sufficient to block the progressive establishment of generalized seizures produced normally by repetitive electrical stimulation of the amygdala. However, a focal afterdischarge persists during the entire treatment. Higher doses (75-150 mg/kg) are necessary to protect the animal against the generalized tonic-clonic seizure when the kindling phenomenon is established. These effects and the action of barbiturates, which was also tested, seem to attribute to VPA a complex role in the mechanism of this action.
描述了抗癫痫药物丙戊酸（VPA）对一种实验性癫痫即点燃现象的作用。在猫身上，每天腹腔注射50毫克/千克足以阻断通常由杏仁核重复电刺激产生的全身性癫痫发作的逐步形成。然而，在整个治疗过程中会持续存在局灶性放电后电位。当点燃现象形成后，需要更高剂量（75 - 150毫克/千克）来保护动物免受全身性强直阵挛性发作。还测试了巴比妥类药物的作用，这些作用似乎使VPA在该作用机制中具有复杂的作用。
