年龄、细胞免疫与重度抑郁症中的下丘脑-垂体轴

Age, cellular immunity and the HP axis in major depression.

Darko D F, Lucas A H, Gillin J C, Risch S C, Golshan S, Hamburger R N, Silverman M B, Janowsky D S

San Diego Veterans Administration Medical Center, Department of Psychiatry.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):713-20. doi: 10.1016/0278-5846(88)90016-4.

Abstract

To assess the effect of age on cellular immune status and the HP axis in patients with major depression, we examined peripheral blood mononuclear cells (PBMC) and measured the plasma level of four neurohormones. 2. In 36 subjects, decreasing T lymphocyte response to con A covaried with age. Percent of lymphocytes labeled as T8 lymphocytes tended to decrease and T4/T8 ratio tended to increase with increasing age. 3. Hamilton and Beck scores were significantly different between the two sex and race matched groups of 18 depressed patients and 18 control subjects, and plasma prolactin was significantly higher in depressed subjects. 4. Increasing age correlated with decreasing T lymphocyte response to con A in the combined group of all subjects, and in the control group, but not in the patient group. 5. Hamilton and Beck scores correlated inversely with T lymphocytes response in the combined group of all subjects. 6. Differences in mitogen responsiveness between patient and control groups were not found, having been obscured by the effect of age. 7. These findings indicate the need to age match subjects when studying the interaction between depression and immune cell function.

摘要

为评估年龄对重度抑郁症患者细胞免疫状态和下丘脑 - 垂体轴（HP轴）的影响，我们检测了外周血单核细胞（PBMC）并测定了四种神经激素的血浆水平。2. 在36名受试者中，T淋巴细胞对刀豆蛋白A的反应随年龄增长而降低。随着年龄的增加，标记为T8淋巴细胞的百分比趋于下降，而T4/T8比值趋于上升。3. 在18名抑郁症患者和18名对照受试者这两组性别和种族匹配的人群中，汉密尔顿评分和贝克评分存在显著差异，抑郁症患者的血浆催乳素水平显著更高。4. 在所有受试者的合并组以及对照组中，年龄增长与T淋巴细胞对刀豆蛋白A的反应降低相关，但在患者组中并非如此。5. 在所有受试者的合并组中，汉密尔顿评分和贝克评分与T淋巴细胞反应呈负相关。6. 未发现患者组和对照组之间有丝分裂原反应性的差异，该差异已被年龄效应所掩盖。7. 这些发现表明，在研究抑郁症与免疫细胞功能之间的相互作用时，需要使受试者年龄匹配。