Darko D F, Gillin J C, Risch S C, Bulloch K, Golshan S, Tasevska Z, Hamburger R N
San Diego Veterans Administration Medical Center, CA 92161.
Biol Psychiatry. 1989 Jun;26(2):145-55. doi: 10.1016/0006-3223(89)90018-8.
To assess cellular immune status and the hypothalamic-pituitary (HP) axis in patients with major depression, we examined peripheral blood mononuclear cells (PBMC) and measured the plasma levels of cortisol, adrenocorticotropin hormone (ACTH), growth hormone (GH), and prolactin (PRL). Twenty patients with major depression were compared with 20 control subjects matched for age, sex, and race. The dose-response curves for concanavalin-A (Con-A) and phytohemagglutinin (PHA) stimulation were not significantly different between the two groups. The patients had decreased Con-A-stimulated T-lymphocyte proliferation when compared to the control subjects, but only at the lowest suboptimal concentration of Con-A. None of the four concentrations of PHA-stimulated proliferation were different between the two groups, neither was PHA-induced interleukin-2 production. Within the patient group only, plasma prolactin (PRL) correlated significantly with stimulated lymphocyte proliferation using two optimal concentrations of PHA and one optimal concentration of Con-A, when the proliferation was expressed using the stimulation index.
为评估重度抑郁症患者的细胞免疫状态和下丘脑 - 垂体（HP）轴，我们检测了外周血单个核细胞（PBMC），并测量了血浆中皮质醇、促肾上腺皮质激素（ACTH）、生长激素（GH）和催乳素（PRL）的水平。将20例重度抑郁症患者与20名年龄、性别和种族相匹配的对照受试者进行比较。两组之间伴刀豆球蛋白A（Con - A）和植物血凝素（PHA）刺激的剂量反应曲线无显著差异。与对照受试者相比，患者在Con - A刺激下T淋巴细胞增殖减少，但仅在最低的次优浓度Con - A时出现。两组之间四种浓度的PHA刺激增殖均无差异，PHA诱导的白细胞介素 - 2产生也无差异。仅在患者组中，当使用刺激指数表示增殖时，血浆催乳素（PRL）与使用两种最佳浓度的PHA和一种最佳浓度的Con - A刺激的淋巴细胞增殖显著相关。
