Darko D F, Gillin J C, Risch S C, Bulloch K, Golshan S, Tasevska Z, Hamburger R N
Mental Health Clinic, San Diego Veterans Administration Medical Center, CA 92161.
Psychiatry Res. 1988 Aug;25(2):173-9. doi: 10.1016/0165-1781(88)90048-0.
To explore changes in immune cell status with changes in the hypothalamic-pituitary (HP) axis in 20 patients with major depression as compared with 20 age-, sex-, and race-matched control subjects, we examined peripheral blood mononuclear cells (PBMC) for total T-cells (T3), total B-cells (B1), two T-cell subsets (T4 and T8), and natural killer cells (NKH1), and we measured the plasma level of cortisol, adrenocorticotropic hormone (ACTH), growth hormone (GH), and prolactin (PRL). The ratio of T4/T8 was increased in the patients. Within the group of control subjects only, increasing age correlated significantly with decreasing plasma PRL. Within the group of patients only, GH positively correlated significantly with T8 and NKH1, as did PRL with NKH1. No between-groups difference was found for T3, B1, T4, T8, NKH1, cortisol, ACTH, GH, or PRL.
为了探究20例重度抑郁症患者与20例年龄、性别和种族匹配的对照受试者相比，免疫细胞状态随下丘脑 - 垂体（HP）轴变化的情况，我们检测了外周血单个核细胞（PBMC）中的总T细胞（T3）、总B细胞（B1）、两个T细胞亚群（T4和T8）以及自然杀伤细胞（NKH1），并测量了血浆皮质醇、促肾上腺皮质激素（ACTH）、生长激素（GH）和催乳素（PRL）的水平。患者组中T4/T8比值升高。仅在对照组中，年龄增长与血浆PRL水平降低显著相关。仅在患者组中，GH与T8和NKH1显著正相关，PRL与NKH1也显著正相关。在T3、B1、T4、T8、NKH1、皮质醇、ACTH、GH或PRL方面，未发现组间差异。
