• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Efficacy of Topical Timolol versus Saline in Chronic Venous Ulcers: A Randomized Controlled Trial.

作者信息

Rai Abhay K, Janani K, Rai Reena

机构信息

Department of Dermatology, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India.

出版信息

J Cutan Aesthet Surg. 2020 Jan-Mar;13(1):18-23. doi: 10.4103/JCAS.JCAS_13_19.

DOI:10.4103/JCAS.JCAS_13_19
PMID:32655246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7335479/
Abstract

BACKGROUND

Chronic venous ulcers sometimes fail to heal in spite of adequate treatment. Nonhealing is possibly because of chronic activation of β-2 adrenergic receptor (B2-AR) in the keratinocytes by endogenously generated catecholamines, which inhibits keratinocyte migration. Blocking of B2-AR using β-blockers has been reported to promote wound healing through keratinocyte migration, angiogenesis, and fibroblast migration. Topical timolol, a B2-AR antagonist, is used to promote wound healing.

AIMS AND OBJECTIVES

The aim of this study was to compare the efficacy of topical timolol versus saline in chronic venous leg ulcers and to compare the mean reduction in ulcer area at the end of 4 weeks.

MATERIALS AND METHODS

Twenty patients were randomized into two groups. Patients in Group 1 were treated with one drop of 0.5% topical timolol every alternate days for 4 weeks. Ulcer margins were measured and ulcer area calculated every week for 4 weeks. Similar dressing and measurement were carried out for patients with saline for 4 weeks. Healing rate was assessed by the percentage of reduction of ulcer area of both groups at week 4.

RESULTS

The mean reduction in the ulcer size in timolol group was 86.80%, and in saline group 43.82% at the end of 4 weeks.

CONCLUSION

Topical timolol is an easy, noninvasive therapy that can be recommended for chronic ulcer.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/a42c7a16244d/JCAS-13-18-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/d33fb0b0e808/JCAS-13-18-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/3f6ece6c5ef6/JCAS-13-18-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/28a6b1b082b9/JCAS-13-18-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/8d3e3211d68c/JCAS-13-18-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/a42c7a16244d/JCAS-13-18-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/d33fb0b0e808/JCAS-13-18-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/3f6ece6c5ef6/JCAS-13-18-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/28a6b1b082b9/JCAS-13-18-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/8d3e3211d68c/JCAS-13-18-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7db0/7335479/a42c7a16244d/JCAS-13-18-g005.jpg

相似文献

1
Efficacy of Topical Timolol versus Saline in Chronic Venous Ulcers: A Randomized Controlled Trial.
J Cutan Aesthet Surg. 2020 Jan-Mar;13(1):18-23. doi: 10.4103/JCAS.JCAS_13_19.
2
Evaluation of timolol maleate gel for management of hard-to-heal chronic venous leg ulcers. Phase II randomised-controlled study.评价马来酸噻吗洛尔凝胶治疗难以愈合的慢性静脉性腿部溃疡。II 期随机对照研究。
Ann Dermatol Venereol. 2021 Dec;148(4):228-232. doi: 10.1016/j.annder.2020.11.009. Epub 2021 Feb 4.
3
Topical timolol promotes healing of chronic leg ulcer.局部用噻吗洛尔促进慢性腿部溃疡愈合。
J Vasc Surg Venous Lymphat Disord. 2017 Nov;5(6):844-850. doi: 10.1016/j.jvsv.2017.04.019. Epub 2017 Aug 7.
4
Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers.自体血小板作为慢性下肢静脉溃疡辅助治疗的随机试验及局部生物学效应
J Vasc Surg. 2003 Dec;38(6):1342-8. doi: 10.1016/s0741-5214(03)00908-x.
5
Comparison of Efficacy of Autologous Platelet-rich Fibrin versus Saline Dressing in Chronic Venous Leg Ulcers: A Randomised Controlled Trial.自体富血小板纤维蛋白与生理盐水敷料治疗下肢慢性静脉溃疡疗效比较：一项随机对照试验
J Cutan Aesthet Surg. 2017 Jan-Mar;10(1):8-12. doi: 10.4103/JCAS.JCAS_137_16.
6
Antibiotics and antiseptics for venous leg ulcers.用于下肢静脉溃疡的抗生素和防腐剂
Cochrane Database Syst Rev. 2013 Dec 23(12):CD003557. doi: 10.1002/14651858.CD003557.pub4.
7
Antibiotics and antiseptics for venous leg ulcers.用于下肢静脉溃疡的抗生素和防腐剂
Cochrane Database Syst Rev. 2010 Jan 20(1):CD003557. doi: 10.1002/14651858.CD003557.pub3.
8
A Randomized, Controlled Trial to Assess the Effect of Topical Insulin Versus Normal Saline in Pressure Ulcer Healing.一项评估局部应用胰岛素与生理盐水对压疮愈合效果的随机对照试验。
Ostomy Wound Manage. 2016 Jun;62(6):16-23.
9
Antibiotics and antiseptics for venous leg ulcers.用于下肢静脉性溃疡的抗生素和防腐剂。
Cochrane Database Syst Rev. 2008 Jan 23(1):CD003557. doi: 10.1002/14651858.CD003557.pub2.
10
Comparison of Efficacy of Autologous Platelet-Rich Fibrin versus Unna's Paste Dressing in Chronic Venous Leg Ulcers: A Comparative Study.自体富血小板纤维蛋白与尤纳氏糊剂敷料治疗慢性下肢静脉溃疡的疗效比较：一项对比研究。
Indian Dermatol Online J. 2020 Jan 13;11(1):58-61. doi: 10.4103/idoj.IDOJ_119_19. eCollection 2020 Jan-Feb.

引用本文的文献

1
Effect of Topical Timolol on Healing of Immature Breast Scars After Mammoplasty: A Randomized Controlled Trial With Blinded Assessors and Patients.局部用噻吗洛尔对乳房成形术后未成熟乳房瘢痕愈合的影响：一项评估者和患者双盲的随机对照试验
J Cosmet Dermatol. 2025 Jun;24(6):e70261. doi: 10.1111/jocd.70261.
2
One Molecule, Many Faces: Repositioning Cardiovascular Agents for Advanced Wound Healing.一种分子，多种用途：重新定位心血管药物以促进创面愈合。
Molecules. 2024 Jun 20;29(12):2938. doi: 10.3390/molecules29122938.
3
Alpha and beta adrenergic receptors modulate keratinocyte migration.

本文引用的文献

1
Topical timolol promotes healing of chronic leg ulcer.局部用噻吗洛尔促进慢性腿部溃疡愈合。
J Vasc Surg Venous Lymphat Disord. 2017 Nov;5(6):844-850. doi: 10.1016/j.jvsv.2017.04.019. Epub 2017 Aug 7.
2
Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes.急性创伤会改变角质形成细胞中的β2-肾上腺素能信号传导和儿茶酚胺合成途径。
J Invest Dermatol. 2014 Aug;134(8):2258-2266. doi: 10.1038/jid.2014.137. Epub 2014 Mar 10.
3
Topical timolol for a chronic ulcer--a case with its own control.
α 和β 肾上腺素能受体调节角质形成细胞迁移。
PLoS One. 2021 Jul 2;16(7):e0253139. doi: 10.1371/journal.pone.0253139. eCollection 2021.
4
Topical beta-blockers in dermatologic therapy.局部用β受体阻滞剂在皮肤科治疗中的应用。
Dermatol Ther. 2021 Jul;34(4):e15016. doi: 10.1111/dth.15016. Epub 2021 Jun 21.
局部用噻吗洛尔治疗慢性溃疡——自身对照病例
Med J Aust. 2014 Jan 20;200(1):49-50. doi: 10.5694/mja13.10823.
4
Topical timolol for recalcitrant wounds.用于顽固性伤口的局部用噻吗洛尔
JAMA Dermatol. 2013 Dec;149(12):1400-2. doi: 10.1001/jamadermatol.2013.7135.
5
Successful treatment of a chronic venous leg ulcer using a topical beta-blocker.使用局部β受体阻滞剂成功治疗慢性下肢静脉溃疡。
J Am Acad Dermatol. 2013 Oct;69(4):e204-5. doi: 10.1016/j.jaad.2013.06.003.
6
Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study.用于婴儿血管瘤的0.5%或0.1%马来酸噻吗洛尔凝胶形成溶液：一项回顾性、多中心队列研究。
Pediatr Dermatol. 2012 Jan-Feb;29(1):28-31. doi: 10.1111/j.1525-1470.2011.01664.x. Epub 2011 Dec 9.
7
Topical timolol for a refractory wound.局部用噻吗洛尔治疗难治性伤口。
Dermatol Surg. 2012 Jan;38(1):135-8. doi: 10.1111/j.1524-4725.2011.02200.x. Epub 2011 Oct 31.
8
Efficacy of propranolol in wound healing for hospitalized burn patients.普萘洛尔对住院烧伤患者伤口愈合的疗效。
J Burn Care Res. 2009 Nov-Dec;30(6):1013-7. doi: 10.1097/BCR.0b013e3181b48600.
9
Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers.应激介导的全身和局部肾上腺素增加会损害皮肤伤口愈合：β受体阻滞剂的潜在新适应症。
PLoS Med. 2009 Jan 13;6(1):e12. doi: 10.1371/journal.pmed.1000012.
10
Beta adrenergic receptors in keratinocytes.角质形成细胞中的β肾上腺素能受体。
Dermatol Clin. 2007 Oct;25(4):643-53, x. doi: 10.1016/j.det.2007.06.012.