分泌性中耳炎与鼻咽部。一项细菌学和免疫学研究。

Otitis media with effusion and the nasopharynx. A bacteriological and immunological study.

作者信息

Kurono Y, Mogi G

机构信息

Department of Otolaryngology, Medical College of Oita, Japan.

出版信息

Acta Otolaryngol Suppl. 1988;454:214-7. doi: 10.3109/00016488809125030.

DOI:10.3109/00016488809125030

PMID:3265566

Abstract

The adherence of Haemophilus influenzae to nasopharyngeal mucosal cells was investigated in vitro. Secretory IgA antibody activity and the content of fibronectin in nasopharyngeal secretion were determined by enzyme-linked immunosorbent assay. Adherence was greater in children than in adults; and was significantly greater in children with otitis media with effusion than in control children. Secretory IgA and fibronectin in nasopharyngeal secretion were considered to influence adherence of H. influenzae to nasopharyngeal mucosa.

摘要

在体外研究了流感嗜血杆菌对鼻咽部黏膜细胞的黏附情况。采用酶联免疫吸附测定法测定鼻咽部分泌物中的分泌型IgA抗体活性和纤连蛋白含量。儿童的黏附情况比成人更显著；患有渗出性中耳炎的儿童的黏附情况比对照儿童显著更明显。鼻咽部分泌物中的分泌型IgA和纤连蛋白被认为会影响流感嗜血杆菌对鼻咽部黏膜的黏附。