Kamme C, Nilsson N I
Scand J Infect Dis. 1984;16(3):291-6. doi: 10.3109/00365548409070403.
Specimens for bacterial culture were obtained from 117 children with secretory otitis media (SOM). From the nasopharynx Streptococcus pneumoniae, Haemophilus influenzae, Branhamella catarrhalis and group A streptococci were isolated in 79% of the patients. Of 168 ear exudates, 30 yielded growth (18%) from 26 of the patients (22%). Pneumococcal capsular polysaccharides could not be detected in exudates assayed by counterimmunoelectrophoresis. The recovery rate of bacteria from the ear exudates was significantly higher in patients with positive than with negative nasopharyngeal culture (p less than 0.05). The nasopharyngeal pathogens invading the middle ear in SOM seem to survive there for a period of time and are then replaced by other strains according to the fluctuation of the nasopharyngeal flora where approximately 40% of the strains were eliminated and replaced by other strains over a period of 12 to 13 days.
从117例分泌性中耳炎（SOM）患儿获取细菌培养标本。在79%的患者中，从鼻咽部分离出肺炎链球菌、流感嗜血杆菌、卡他布兰汉菌和A组链球菌。168份耳渗出液中，26例患者（22%）的30份（18%）有细菌生长。通过对流免疫电泳检测，在渗出液中未检测到肺炎球菌荚膜多糖。鼻咽培养阳性的患者耳渗出液中细菌的回收率显著高于鼻咽培养阴性的患者（p<0.05）。SOM中侵入中耳的鼻咽病原体似乎在中耳存活一段时间，然后根据鼻咽菌群的波动被其他菌株取代，在12至13天的时间里，约40%的菌株被清除并被其他菌株取代。
