白细胞介素-3和白细胞介素-4均强烈抑制人淋巴因子激活的杀伤细胞（LAK细胞）的诱导及功能。
Interleukin-3 and interleukin-4 each strongly inhibit the induction and function of human LAK cells.
作者信息
Gallagher G, Wilcox F, al-Azzawi F
机构信息
Immunology Division, University of Strathclyde, Glasgow.
出版信息
Clin Exp Immunol. 1988 Nov;74(2):166-70.
We have examined some of the factors which may regulate the generation and function of human lymphokine-activated killer (LAK) cells. In particular we have studied the effect of cytokines other than interleukin-2 on the ability of human LAK cells to kill human tumour cells. By exposing human tumour cells to human LAK-cells in the presence and absence of interleukin-3 or interleukin-4, we were able to demonstrate that each of these cytokines was able to severely reduce the amount of tumour cell killing. Additionally, we examined the effect of interleukin-3 or interleukin-4 on the production in vitro of human LAK cells by including these materials with interleukin-2 while LAK-cells were being induced. These results showed that not only were these cytokines able to inhibit human LAK-cell function, but they were also able to strongly reduce the ability of interleukin-2 to generate human LAK-cells.
我们研究了一些可能调节人淋巴因子激活的杀伤（LAK）细胞生成和功能的因素。特别是，我们研究了白细胞介素-2以外的细胞因子对人LAK细胞杀伤人类肿瘤细胞能力的影响。通过在有和没有白细胞介素-3或白细胞介素-4的情况下将人类肿瘤细胞暴露于人LAK细胞，我们能够证明这些细胞因子中的每一种都能够严重减少肿瘤细胞的杀伤量。此外，我们在诱导LAK细胞时将这些物质与白细胞介素-2一起加入，研究了白细胞介素-3或白细胞介素-4对人LAK细胞体外产生的影响。这些结果表明，这些细胞因子不仅能够抑制人LAK细胞的功能，而且还能够强烈降低白细胞介素-2产生人LAK细胞的能力。
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