Schoonover Kirsten E, Dienel Samuel J, Lewis David A
Translational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, United States.
Medical Scientist Training Program, University of Pittsburgh, United States.
Biomark Neuropsychiatry. 2020 Dec;3. doi: 10.1016/j.bionps.2020.100015. Epub 2020 May 18.
Certain cognitive deficits in schizophrenia, such as impaired working memory, are thought to reflect alterations in the neural circuitry of the dorsolateral prefrontal cortex (DLPFC). Gamma oscillations in the DLPFC appear to be a neural corollary of working memory function, and the power of these oscillations during working memory tasks is lower in individuals with schizophrenia. Thus, gamma oscillations represent a potentially useful biomarker to index dysfunction in the DLPFC circuitry responsible for working memory in schizophrenia. Postmortem studies, by identifying the cellular basis of DLPFC dysfunction, can help inform the utility of biomarker measures obtained . Given that gamma oscillations reflect network activity of excitatory pyramidal neurons and inhibitory GABA neurons, we review postmortem findings of alterations to both cell types in the DLPFC and discuss how these findings might inform future biomarker development and use.
精神分裂症的某些认知缺陷，如工作记忆受损，被认为反映了背外侧前额叶皮质（DLPFC）神经回路的改变。DLPFC中的γ振荡似乎是工作记忆功能的神经必然结果，并且在工作记忆任务期间，精神分裂症患者的这些振荡功率较低。因此，γ振荡代表了一种潜在有用的生物标志物，可用于指示精神分裂症中负责工作记忆的DLPFC神经回路功能障碍。尸检研究通过确定DLPFC功能障碍的细胞基础，有助于了解所获得的生物标志物测量的效用。鉴于γ振荡反映了兴奋性锥体神经元和抑制性GABA神经元的网络活动，我们回顾了DLPFC中这两种细胞类型改变的尸检结果，并讨论了这些结果如何为未来生物标志物的开发和应用提供信息。
