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Nat Med. 2019 May;25(5):767-775. doi: 10.1038/s41591-019-0434-2. Epub 2019 Apr 22.
2
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PLoS Genet. 2018 Mar 14;14(3):e1007227. doi: 10.1371/journal.pgen.1007227. eCollection 2018 Mar.
3
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.DEK缺失诱导小鼠受限造血祖细胞的放射抗性。
Exp Hematol. 2018 Mar;59:40-50.e3. doi: 10.1016/j.exphem.2017.12.009. Epub 2017 Dec 27.
4
Promotion of cell proliferation by the proto-oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization.原癌基因 DEK 通过促进细胞增殖增强口腔鳞状细胞癌的癌变。
Cancer Med. 2017 Oct;6(10):2424-2439. doi: 10.1002/cam4.1157. Epub 2017 Aug 23.
5
Coupling Gd‑DTPA with a bispecific, recombinant protein anti‑EGFR‑iRGD complex improves tumor targeting in MRI.将钆喷酸葡胺与双特异性重组蛋白抗表皮生长因子受体整合素靶向配体（anti-EGFR-iRGD）复合物偶联可改善磁共振成像中的肿瘤靶向性。
Oncol Rep. 2016 Jun;35(6):3227-35. doi: 10.3892/or.2016.4712. Epub 2016 Mar 29.
6
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7
DEK over-expression promotes mitotic defects and micronucleus formation.DEK过表达促进有丝分裂缺陷和微核形成。
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8
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy.肺鳞状细胞癌中未满足的需求：免疫疗法的潜在作用。
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9
High expression of DEK predicts poor prognosis of gastric adenocarcinoma.DEK 高表达预示胃腺癌预后不良。
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DEK 癌基因在鳞状细胞癌发展中的作用。

Role of the DEK oncogene in the development of squamous cell carcinoma.

机构信息

Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Department of Oral Maxillofacial Surgery, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

出版信息

Int J Clin Oncol. 2020 Sep;25(9):1563-1569. doi: 10.1007/s10147-020-01735-5. Epub 2020 Jul 12.

DOI:10.1007/s10147-020-01735-5
PMID:32656741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7441080/
Abstract

DEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes. DEK was discovered to be an oncogene as a fusion with NUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently, DEK overexpression was reported in many cancers, thus DEK itself is considered to be an oncoprotein. DEK has been reported to play important roles in the progression of early and late stage squamous cell carcinoma (SCC) and is useful for early diagnosis of the disease. These findings have made DEK an attractive therapeutic target, especially for human papillomavirus (HPV)-associated SCC. However, the mechanism of DEK in SCC remains unclear. In this review, we discuss human DEK oncogene-related SCC.

摘要

DEK 是一种高度保守的核因子，在调节多种细胞过程中发挥重要作用。DEK 最初被发现是一种癌基因，它与 NUP214 基因融合，导致产生 DEK-NUP214 蛋白，在一部分急性髓系白血病患者中发现。随后，在许多癌症中报道了 DEK 的过度表达，因此 DEK 本身被认为是一种癌蛋白。已有报道称 DEK 在早期和晚期鳞状细胞癌 (SCC) 的进展中发挥重要作用，并且对疾病的早期诊断有用。这些发现使 DEK 成为一个有吸引力的治疗靶点，特别是对于人乳头瘤病毒 (HPV) 相关 SCC。然而，DEK 在 SCC 中的作用机制尚不清楚。在这篇综述中，我们讨论了人类 DEK 癌基因相关 SCC。